Microcirculation in Patients With Leukemic Hyperleukocytosis

Not Applicable

Completed

• Conditions: Hyperleukocytic Syndrome
• Interventions: Diagnostic Test: intravital microscopy

• Registration Number: NCT03729206
• Lead Sponsor: University Hospital Muenster

Brief Summary

Hyperleukocytosis in patients with acute leukemia impacts rheology and microvascularization, leading to severe symptoms or even death. The investigators investigated whether blood stream alterations induced by hyperleukocytosis can be detected by sidestream dark-field imaging and whether they correlate with the grade of symptoms.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-01
• Study First Submitted: 2018-10-31
• Study First Submitted QC: 2018-11-01
• Study First Posted: 2018-11-02
• Primary Completion: 2020-12-01
• Study Completion: 2021-08-01
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-04
• Last Update Posted: 2022-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• acute leukemia
• de-novo or relapsed stage
• able to give consent

Exclusion Criteria

• severe oral mucositis
• unable to give consent
• pregnant women
• patients hospitalized for psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Sublingual microscopy	intravital microscopy	-

Primary Outcome Measures

Name	Time	Method
microvascular flow index (MFI) of sublingual microcirculation	24 months

Trial Locations

Locations (1)

Universitätsklinikum Münster; 🇩🇪 Münster, Germany