A proof-of-concept study to compare the effectiveness and tolerability of convulsive versus sub-convulsive stimuli of modified electroconvulsive therapy - NI

All India Institute of Medical Sciences New Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年7月22日

试验速览

暂无简介。

•1.Age 18-60 years
•2.Willing to give informed consent
•3.Ability to read Hindi or English language
•4.Fulfilling criteria of major depressive disorder as per Diagnostic and Statistical Manual 5th version (DSM 5) in group 1 & 2
•5.Treatment resistance will be defined as the failure to respond to 2 adequate trials of different classes of antidepressant medications (Sackeim, 2001)
•6.Patients referred for ECT (for all study patients, a clinical decision to pursue neuromodulation would have already been made. Clinical treatment will be performed independently of this study).
•7.No changes in psychiatric medications for at least one month prior to study and willingness to not change during study

•1.Patients with chronic neurological or other physical illness (like coronary artery disease or cardiac arrhythmia)
•2.Suffering from any other psychiatric disorder other than major depressive disorder in their respective groups
•3.Persistent mood disorders (dysthymia) and other and unspecified depressions based on DSM 5
•4.History of significant head trauma
•5.Patients with ongoing alcohol or other substance abuse or dependence (except nicotine and caffeine)
•6.Any history of seizure
•7.Previous history of receiving any surgical procedures or electrical or magnetic stimulation on brain
•8.Known or suspected pregnancy or lactating females
•9.History of serious, potentially life-threatening reaction to anesthesia or succinylcholine

发起方

All India Institute of Medical Sciences New Delhi