TCTR20201105004
Not Yet Recruiting
N/A
Magnetic Resonance Elastography of Skeletal muscle in scleroderma with muscle involvement compared to Muscle biopsy: a pilot study
Faculty of medicine0 sites30 target enrollmentNovember 5, 2020
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- -
- Sponsor
- Faculty of medicine
- Enrollment
- 30
- Status
- Not Yet Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Systemic sclerosis, age \>/\= 18 years old
- •2\.Abnormal increased CPK enzyme level above upper normal limited (\> 200 IU/L).
- •3\.Muscle weakness ≤grade IV based on manual muscle testing.
Exclusion Criteria
- •1\.Deny performing muscle biopsy.
- •2\.Ongoing immunosuppressive drug and unable to stop the drug due to prevent disease control flare up during the time of MRE examination (low dose steroid equivalent with prednisolone ≤15 mg/d is allow during MRE examination)
- •3\.Having contraindication to perform muscle biopsy
- •4\.Underlying bleeding disorder or coagulopathy
- •5\.Take any anticoagulant, antiplatelet, or other medicines that affect blood clotting
- •6\.Infection of the biopsy site
- •7\.Absolute contraindication to perform MRI and MRE.
- •8\.Pregnancy or lactation
- •9\.Advanced stage of cancer
Outcomes
Primary Outcomes
Not specified
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