Interference by Activated Protein C Resistance in the Determination of Protein S Activity

Recruiting

• Conditions: Resistance to Activated Protein C in the Determination of Protein S Activity

• Registration Number: NCT06182501
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-01
• Study First Submitted: 2022-09-06
• Status Verified: 2023-12
• Primary Completion: 2023-12
• Study Completion: 2023-12
• Study First Submitted QC: 2023-12-12
• Last Update Submitted: 2023-12-12
• Study First Posted: 2023-12-27
• Last Update Posted: 2023-12-27

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 9470

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional test protein C resistance	Through study completion, an average of 2 months

Trial Locations

Locations (1)

Laboratoire d'Hématologie - CHU de Strasbourg - France; 🇫🇷 Strasbourg, France