Regulation of IL6 / STAT pathway based on microrna-451a Discussion on the prethrombotic state of repeated implant failure treated by Acupuncture Mechanism of actio
- Conditions
- Repeated implantation failure
- Registration Number
- ITMCTR2000004021
- Lead Sponsor
- Fujian Maternity and Child Health Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
1. Patients who meet the diagnostic criteria of Western medicine and traditional Chinese medicine;
2. Patients who have obtained excellent embryos of grade 1-2 after oocyte retrieval;
3. Patients aged 20-40 years;
4. Patients have independent ability, agree to accept the treatment plan of this study, obey the research arrangement, and sign the informed consent.
1. Patients under 20 years old or over 40 years old;
2. Patients with organic diseases or other endocrine diseases were excluded: female genital malformations, including uterine malformations (single horn uterus, double horn uterus, mediastinal uterus and double uterus), adenomyosis, submucosal myoma and intrauterine adhesions, hyperprolactinemia, abnormal thyroid function and other reproductive endocrine diseases and autoimmune diseases;
3. Patients with primary diseases such as liver and kidney, cerebrovascular, cardiovascular and hematopoietic disorders, and psychosis;
4. Patients allergic to aspirin or other salicylates or other components of drugs;
5. Patients with history of gastric or duodenal ulcer or gastrointestinal bleeding or other cases of aspirin forbidden;
6. Data were incomplete.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expression and phosphorylation of JAK and stat related proteins;Coagulation related indicators;TCM symptom score;JAK, stat and other gene transcription levels;pregnancy outcome;
- Secondary Outcome Measures
Name Time Method Safety inspection index;