Is the IVF Outcome Dependent on the Time Interval Between hCG Administration and Oocyte Retrieval?

Not Applicable

Completed

• Conditions: Subfertility
• Interventions: Procedure: Oocyte retrieval will be performed 36 h or 38 h after hCG administration

• Registration Number: NCT02044445
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH. The hCG is administered when more than three follicles ≥17mm in mean diameter have developed.

The time interval between hCG administration and oocyte retrieval is of critical importance since the time after luteinizing stimulus is a period of intense processes including the start of luteinization, expansion of cumulus cells and oocyte meiotic maturation.

The commonly practiced hCG administration time of 33 to 36 h in most IVF cycles aims to avoiding spontaneous ovulation before oocyte retrieval. However, several studies have shown that significantly more high quality embryos have been obtained with a prolonged hCG-to-oocyte interval of 38 h. It has been hypothesized that longer interval would be beneficial in improving oocyte quality and achieving optimal maturation.

Currently there are no data on the effect of the time interval between hCG administration and oocyte retrieval on IVF outcome in GnRH antagonist cycles. The aim of this study is to determine whether there is any difference in in vitro fertilization outcome when oocyte retrieval takes place at 36 h or 38 h following hCG administration

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2013-10-10
• Primary Completion: 2013-12
• Study First Submitted QC: 2014-01-23
• Study First Posted: 2014-01-24
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-26
• Last Update Posted: 2014-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 154

Inclusion Criteria

• women undergoing fresh IVF cycle with recombinant FSH and GnRH antagonists
• regular spontaneous menstrual cycle (24-35 days)
• age ≤ 43 years
• FSH ≤ 20 IU/L

Exclusion Criteria

• History of previous ovarian surgery
• Women with Stage III-IV Endometriosis
• Women undergoing natural cycle IVF

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
36 h group	Oocyte retrieval will be performed 36 h or 38 h after hCG administration	Oocyte retrieval will be performed 36 hours after hCG administration
38 h group	Oocyte retrieval will be performed 36 h or 38 h after hCG administration	Oocyte retrieval will be performed 38 hours after hCG administration

Primary Outcome Measures

Name	Time	Method
retrieval rate (cumulus-oocyte complexes/ follicles> 11 mm)	up to 38 h after hCG administration

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate (evidence of intrauterine sac with fetal heart activity at 6-8 weeks of gestation)	At 6-8 weeks of gestation
Total number of oocytes retrieved	up to 38 h after hCG administration

Trial Locations

Locations (1)

Unit for Human Reproduction, 1st Dept of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki; 🇬🇷 Thessaloniki, Greece