Effects of Negative Pressure Ventilation on Right Ventricular Function in Cardiological Patients With Reduced Right Ventricular Function.
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Karlsburg Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- stroke volume index
Overview
Brief Summary
Patients receives induction of general anesthesia for interventional tricuspidal clipping and standard monitoring for this procedure including arterial and central venous line and transesophageal ultrasound. A cuirass for extrathoracal negative pressure ventilation is placed onto the chest but not switched on. During usual positive pressure ventilation a ventilatory, a hemodynamic and a 3D full volume ultrasounddataset of the right and left ventricle is recorded and severity of tricuspidal regurgitation examined. Afterwards negative pressure ventilation is started and positive pressure ventilation reduced as far as possible without reduction of tidal volumes. The same dataset of ventilation, hemodynamics and ultrasound is collected again during negative pressure ventilation. Afterwards the cuirass gets removed, study finished and everything proceeds as during standard procedure.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Other
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients planned for tricuspidal clipping
Exclusion Criteria
- •ventilatory of hemodynamic instability
- •fitting of cuirass not possible
- •unavailability of examiner
Outcomes
Primary Outcomes
stroke volume index
Time Frame: 1 minute
transesophageal ultrasound measurement
Secondary Outcomes
- RVEF(1 minute)
- strain(1 minute)
- heart frequency(1 minute)
- volumes of chambers(1 minute)
- breathing rate(1 minute)
- pO2 in the blood(1 minute)
- pCO2 in the blood(1 minute)
- PISA(1 minute)
- EROA(1 minute)
- area of regurgitation of tricuspid valve(1 minute)
- arterial blood pressures(1 minute)
- LVEF(1 minute)
- pulmonal blood pressures(1 minute)
- VC(1 minute)
- venous blood pressures(1 minute)
- tidal volume(1 minute)
- etCO2(1 minute)
- minute volume(1 minute)
- Laktat(1 minute)
- cerebral oximetry(1 minute)
Investigators
Prof. Dr. Matthias Heringlake
Principal Investigator
Karlsburg Hospital