Hemodynamic Effects of Negative Pressure Ventilation in Chronic Obstructive Pulmonary Disease
- Conditions
- COPD
- Registration Number
- NCT04212559
- Lead Sponsor
- Fu Jen Catholic University
- Brief Summary
Negative pressure ventilation (NPV) is a non-invasive ventilation mode which provide better lung expansion. The major complication of NPV is decrease blood pressure and affects the hemodynamics. The effects of NPV on chronic obstructive pulmonary disease (COPD) patients with pulmonary rehabilitation program remains unknown.
- Detailed Description
Both of NPV or positive pressure ventilation (PPV) has impact of hemodynamics. NPV with cuirass ventilator increases venous return and leads to ventricular filling and increases cardiac output (CO); In contrast to NPV, the effect of PPV in most situations is a decreased venous return and leads to decreased CO. NPV improving ventilation and work of breathing in patients with chronic obstructive pulmonary disease (COPD).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Patients with COPD who received pulmonary rehabilitation program with NPV treatment
- Recent exacerbation within 3-months
- Existing of tracheostomy
- Absence of NPV used
- Required of oxygen supplement during NPV
- Diagnosed of neuromuscular disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CO (cardiac output) 20 minutes Change of Cardiac output before and after NPV treatment
SV (stroke volume) 20 minutes Change of stroke volume before and after NPV treatment
- Secondary Outcome Measures
Name Time Method SpO2 20 minutes Change of oxygen saturation before and after NPV treatment
RR (respiratory rate) 20 minutes Change of respiratory rate before and after NPV treatment
Trial Locations
- Locations (1)
Fu Jen Catholic University Hospital, Fu Jen Catholic University
🇨🇳New Taipei City, Taiwan
Fu Jen Catholic University Hospital, Fu Jen Catholic University🇨🇳New Taipei City, Taiwan