Hemodynamic Effects of Negative Pressure Ventilation in Chronic Obstructive Pulmonary Disease Assessed Using Non-Invasive Electrical Cardiometry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- Fu Jen Catholic University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- CO (cardiac output)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Negative pressure ventilation (NPV) is a non-invasive ventilation mode which provide better lung expansion. The major complication of NPV is decrease blood pressure and affects the hemodynamics. The effects of NPV on chronic obstructive pulmonary disease (COPD) patients with pulmonary rehabilitation program remains unknown.
Detailed Description
Both of NPV or positive pressure ventilation (PPV) has impact of hemodynamics. NPV with cuirass ventilator increases venous return and leads to ventricular filling and increases cardiac output (CO); In contrast to NPV, the effect of PPV in most situations is a decreased venous return and leads to decreased CO. NPV improving ventilation and work of breathing in patients with chronic obstructive pulmonary disease (COPD).
Investigators
Ke-Yun, Chao
Head of Respiratory Therapist
Fu Jen Catholic University
Eligibility Criteria
Inclusion Criteria
- •Patients with COPD who received pulmonary rehabilitation program with NPV treatment
Exclusion Criteria
- •Recent exacerbation within 3-months
- •Existing of tracheostomy
- •Absence of NPV used
- •Required of oxygen supplement during NPV
- •Diagnosed of neuromuscular disease
Outcomes
Primary Outcomes
CO (cardiac output)
Time Frame: 20 minutes
Change of Cardiac output before and after NPV treatment
SV (stroke volume)
Time Frame: 20 minutes
Change of stroke volume before and after NPV treatment
Secondary Outcomes
- SpO2(20 minutes)
- RR (respiratory rate)(20 minutes)