Effect of intraoperative magnesium and ketamine combination on postoperative pain after abdominal hysterectomy
Not Applicable
- Conditions
- Acute postoperative pain.R52.0 Acute PainR50-R69
- Registration Number
- IRCT201608157013N12
- Lead Sponsor
- Vice chancellor for reaserch, Tabriz University of Medical Scienses
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 66
Inclusion Criteria
Scheduled for elective abdominal hysterectomy; ASA class I, II. Exclusion criteria: Emergence hysterectomy; history of systemic diseases (renal, cardiovascular; respiratory, hepatic, neuromuscular and ...); history of psychopathy; BMI>35; calcium Chanel inhibitor consumption; recent magnesium therapy; history of chronic pain syndrome; pregnancy; history of alcohol and opioid consumption
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: PACU and at 1, 3, 6, 12 and 24h after surgery. Method of measurement: visual analogue scale(VAS) (0= non to 10= severe pain) cm).
- Secondary Outcome Measures
Name Time Method Overall dose of postoperative analgesic. Timepoint: PACU and during 24h postoperatively. Method of measurement: number and amount of medication by mg.
Related Research Topics
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How does the magnesium-ketamine combination modulate NMDA receptor antagonism and calcium channel inhibition in postoperative pain management?
What is the comparative efficacy of intraoperative magnesium and ketamine versus standard opioid-based analgesia in abdominal hysterectomy patients?
Which biomarkers correlate with response to magnesium-ketamine adjuvant analgesia in acute postoperative pain (R52.0) following abdominal hysterectomy?
What adverse events are associated with intraoperative magnesium and ketamine administration in postoperative pain control, and how are they managed?
Are there alternative NMDA receptor antagonist combinations or adjuvants being evaluated for acute postoperative pain management by Tabriz University researchers?