Gait Analysis Parameter, Stair Climbing and Upper Limb Evaluation in Patients With Muscular Pathology and in Control Subjects: The ActiLiège Next Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Duchenne Muscular Dystrophy
- Sponsor
- Centre Hospitalier Universitaire de Liege
- Enrollment
- 300
- Locations
- 8
- Primary Endpoint
- Stride velocity
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
The objective of the ActiLiège Next study is to collect longitudinal data from patients and control subjects using a wearable magneto-inertial device. By collecting natural history data in various neuromuscular disorders (Duchenne Muscular Dystrophy, Fascioscapulohumeral Muscular Dystrophy, Myotonic Dystrophy 1, Charcot-Marie-Tooth, Centronuclear Myopathy, Congenital Muscular Dystrophy), we aim to validate digital outcome measures to continuously assess motor function in real-life.
Investigators
Laurent Servais
Professor Laurent Servais
Centre Hospitalier Universitaire de Liege
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •For the patients:
- •Patients with extreme cognitive disorders that limit their understanding of the exercises to be performed.
- •Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the upper or lower limbs (for ambulant patients).
- •A concomitant chronic or acute neurological, endocrine, infectious, allergic, or inflammatory pathology within the 3-week period immediately prior to inclusion.
- •Patients who are participating in an interventional clinical trial.
- •DMD patients in transition who are not on corticosteroids.
- •For the control subjects:
- •Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the upper or lower limbs.
- •Elite athletes (at the national level).
- •A chronic or acute muscular, neurological, infectious, or inflammatory pathology within the 3-week period immediately prior to inclusion.
Outcomes
Primary Outcomes
Stride velocity
Time Frame: through study completion (3 year)
Stride velocity obtained with a magneto-inertial sensor (Actimyo°) in real-life (meter per second).
Stride length
Time Frame: through study completion (3 year)
Stride length obtained with a magneto-inertial sensor (Actimyo°) in real-life (meter).
Stairs height
Time Frame: through study completion (3 year)
Height of the strides in stairs obtained with a magneto-inertial sensor (Actimyo°) in real-life
Stairs speed
Time Frame: through study completion (3 year)
Vertical speed during strides in stairs obtained with a magneto-inertial sensor (Actimyo°) in real-life
Stairs number
Time Frame: through study completion (3 year)
Total number of strides in stairs obtained with a magneto-inertial sensor (Actimyo°) in real-life