Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions

Recruiting

• Conditions: Gait Analysis in Neurological Disorders

• Registration Number: NCT02165787
• Lead Sponsor: University of Zurich

Brief Summary

In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2014-05-23
• Study First Submitted QC: 2014-06-13
• Study First Posted: 2014-06-17
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-12
• Last Update Posted: 2024-11-14
• Primary Completion: 2025-03
• Study Completion: 2025-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 340

Inclusion Criteria

Patients:

• age 18 - 80
• written, informed consent
• one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis
• Brain and whole spine T1, T2 & FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans

Healthy subjects:

• age 18 - 80
• written informed consent

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Exclusion Criteria

Patients:

• Colour-blindness
• Known to be pregnant or breastfeeding
• Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol
• Terminal diagnosis with life expectancy less than six months
• Cognitive disturbance defined as MMSE < 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease

Healthy subjects:

• Colour-blindness
• Known to be pregnant or breastfeeding
• Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes
• Reliance on walking aids / prostheses for mobilisation
• Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of gait parameter after injury to CNS	Timepoint 0 plus timepoint 6 months and 12 months

Trial Locations

Locations (1)

University of Zurich; 🇨🇭 Zurich, Switzerland