Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gait Analysis in Neurological Disorders
- Sponsor
- University of Zurich
- Enrollment
- 208
- Locations
- 1
- Primary Endpoint
- Change of gait parameter after injury to CNS
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age 18 - 80
- •written, informed consent
- •one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis
- •Brain and whole spine T1, T2 \& FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans
- •Healthy subjects:
- •age 18 - 80
- •written informed consent
Exclusion Criteria
- •Colour-blindness
- •Known to be pregnant or breastfeeding
- •Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol
- •Terminal diagnosis with life expectancy less than six months
- •Cognitive disturbance defined as MMSE \< 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease
- •Healthy subjects:
- •Colour-blindness
- •Known to be pregnant or breastfeeding
- •Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes
- •Reliance on walking aids / prostheses for mobilisation
Outcomes
Primary Outcomes
Change of gait parameter after injury to CNS
Time Frame: Timepoint 0 plus timepoint 6 months and 12 months