Gait, cOgnitiOn & Decline (GOOD)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 2,800
- 试验地点
- 1
- 主要终点
- Spatio-temporal gait parameters
研究概览
简要总结
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.
详细描述
Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.
The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being 60 years old and older
- •Ability to answer questions
排除标准
- •Opposition to the use of information collected for research purposes
结局指标
主要结局
Spatio-temporal gait parameters
时间窗: This outcome is assessed at inclusion
Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system.
次要结局
- Clinical assessment(This outcome is assessed at inclusion)
- Cognitive status(This outcome is assessed at inclusion)