retrospective study of gamma knife radiosurgery for brain metastases of small cell lung carcinoma after whole brain radiotherapy
- Conditions
- brain metastases of small cell lung carcinoma
- Registration Number
- JPRN-UMIN000027490
- Lead Sponsor
- Japan Leksell Gamma Knife Society
- Brief Summary
The median OS was 9.3 months and the neurologic mortality was 20.0%. Local control failure and new lesion appearance were 36.6% and 64.9%. A BM diameter > 1.0 cm was a significant risk factor for local progression and neurologic death. The symptom improvement was 61.3% and neurological function was preserved for 7.6 months. Therapeutic WBRT was not a significant risk factor for OS, neurological death, local control, or functional deterioration. Symptomatic ARE were 7.4%
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 163
Not provided
1 gamma knife radiosurgery before whole brain radiotherapy 2 presence of leptomeningeal dissemination 3 surgery for brain metastases before gamma knife radiosurgery 4 intracranial metastases outside of brain 5 Karnofsky performance status <70 or no expectation for improvement of KPS >60 after gamma knife radiosurgery 6 gamma knife radiosurgery without gadlinium enhancement MRI 7 the number of brain metastases >10 or the total volume of brain metastases >15ml or the volume of maximum brain metastasis >10ml
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method