Confounding Factors in Ocular Surface Microbiome Research
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 450
- 试验地点
- 2
- 主要终点
- Change in richness and evenness of distribution of the microbial flora, measured as operational taxonomic units, over time
研究概览
简要总结
To elucidate confounding factors in ocular surface microbiome research and to confirm the presence of a core ocular surface microbiome and its temporal stability.
详细描述
The investigator will take a conjunctival sample of both eyes of a group of volunteers together with an extensive questionnaire. Furthermore, 50 volunteers will be sampled repeatedly during one year or two years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The subject is fluent in written and verbal Dutch
- •The subject is capable of giving informed consent
排除标准
- •Use of glaucoma drops
- •Use of antibiotic drops < 1 month before sampling
结局指标
主要结局
Change in richness and evenness of distribution of the microbial flora, measured as operational taxonomic units, over time
时间窗: 20 minutes for the first sample and questionnaire, 5 minutes for all other visits
A conjunctival swab will be taken on different points in time to investigate the temporal stability of the conjunctival microbial flora
Richness and evenness of distribution of the microbial flora measured as operational taxonomic units on a single moment
时间窗: 20 minutes for samples and filling the questionnaires
A conjunctival swab and extensive questionnaire will be taken to search for a core ocular surface microbiome and confounding factors
次要结局
未报告次要终点