Cerebral Oximetry in Relation to Pulmonary Artery Catheter Parameters and Extracorporeal Membrane Oxygenation Flow in Patients Supported With Veno-arterial ECMO
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- correlation between native cardiac output/ Extracorporeal membrane oxygenation flow ratio and regional cerebral tissue oxygen saturation
研究概览
简要总结
for patients connected to VA ECMO due to cardiogenic shock, monitoring:
- Cerebral Oximetry
- ECMO Parameters ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration
- Pulmonary Artery Catheter Data and hemodynamics:
Cardiac output / cardiac index, SvO₂, Central venous pressure (CVP). 4. other variables: P/F ratio, MAP, Heart rate, Arterial blood gases, hemoglobin, Lactate, Vasopressor / inotrope doses and Sedation score (RASS). 5. Echocardiography parameters: recorded every 12 hours. LV ejection fraction. LVOT VTi. LVED dimension. Aortic valve opening. 6. Follow-up data:
- ECMO duration.
- Need for oxygen therapy/mechanical ventilation.
- ICU survival.
详细描述
for patients connected to VA ECMO due to cardiogenic shock, monitoring:
- Cerebral Oximetry
Bilateral frontal sensors, rScO₂ recorded:
at baseline (within 1 hour of ECMO initiation) then every 12 hours. 2. ECMO Parameters Pump speed (RPM) ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration Arterial cannulation site 3. Pulmonary Artery Catheter Data and hemodynamics:
Cardiac output / cardiac index every 12 hours. SvO₂. Central venous pressure (CVP) Mean pulmonary artery pressure. Pulmonary capillary wedge pressure. Systemic vascular resistance. 4. Echocardiography parameters: recorded every 12 hours. LV ejection fraction. LVOT VTi. LVED dimension. Aortic valve opening. 5. Other variables:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Patients supported with veno-arterial ECMO.
- •Presence of a pulmonary artery catheter.
- •Expected ECMO support ≥ 24 hours.
- •Patient with good echocardiographic window.
排除标准
- •Pre-existing severe neurological injury (e.g. massive stroke, traumatic brain injury).
- •Intracranial pathology affecting NIRS reliability.
- •Facial or scalp conditions preventing NIRS probe placement.
- •ECMO duration < 48 hours.
- •Poor echocardiographic window.
结局指标
主要结局
correlation between native cardiac output/ Extracorporeal membrane oxygenation flow ratio and regional cerebral tissue oxygen saturation
时间窗: from date of randomization until the date of ending the ECMO support (assessed up to 100 weeks)
次要结局
未报告次要终点
研究者
Doaa Roshdy Abdul Satar Mohamed
Assistant lecturer
Assiut University