NCT03532438Unknown不适用
Whole Genome Sequencing of Nontuberculous Mycobacterium (NTM) Derived From Sputum Specimen of NTM Lung Disease Patients Living Together and From Their Environmental Samples
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Genetic similarity of NTM(Non-Tuberculous Mycobacterium)
研究概览
简要总结
The purpose of the study is to identify the genetic closeness of NTM derived from patients living together and from their surrounding environment and to trace the temporal relationship between them.
详细描述
After NTM isolation is done by using culture, from patients' sputum/bronchoscopic samples and their environmental samples, whole genome sequencing (WGS) will be conducted for all NTM isolates. Phylogenetic analysis will be performed based on single nucleotide polymorphism (SNP) on each NTM.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The adult over 18 years of age
- •The patient who have respiratory symptoms consistent with NTM, such as a chronic cough, sputum, and hemoptysis, who have NTM-positive findings on CT, and who have NTM identification in two or more sputum cultures or in one or more bronchoscopic/tissue culture. (2007 ATS/IDSA guideline)
- •Pairs of patients living in the same household since diagnosis on NTM lung disease
- •Consent to a collection of environmental samples from the patient's residence.
排除标准
- •If the patient does not agree or withdraw.
结局指标
主要结局
Genetic similarity of NTM(Non-Tuberculous Mycobacterium)
时间窗: Baseline
Concordance of Single Nucleotide Polymorphisms (SNP) from NTMs derived from patients and their environments
次要结局
未报告次要终点
研究者
Jae-Joon Yim
Professor
Seoul National University Hospital
研究点 (1)
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