Elucidation of Genetic Susceptibility of Patients With Nontuberculous Mycobacterial Lung Disease Using Genome-Wide Association Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,808
- 试验地点
- 1
- 主要终点
- Finding of single nucleotide polymorphisms (SNPs) associated with the risk of NTM lung disease compared with controls
研究概览
简要总结
The aim of this study was to elucidate genetic susceptibility of patients with nontuberculous mycobacterial lung disease using genome-wide association study.
详细描述
Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms. NTM lung disease is increasing, however, genetic susceptibility of patients with the disease have not been identified. To elucidate the genetic susceptibility of NTM lung disease, the investigators perform a genome-wide association study (GWAS) including patients with NTM lung disease and healthy controls (case : control = 1 : 3). The age-, sex-matched control group will be recruited from the Korean Healthy Twin Study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Case: Patients with NTM lung disease satisfying diagnostic criteria suggested by American Thoracic Society
- •Control: Healthy subjects enrolled in the Korean Healthy Twin Study
排除标准
- •Case: none
- •Control: 1) Subjects who have respiratory symptoms including cough and sputum 2) Subjects who have abnormalities on chest radiography
结局指标
主要结局
Finding of single nucleotide polymorphisms (SNPs) associated with the risk of NTM lung disease compared with controls
时间窗: Baseline
To identify SNPs related to NTM lung disease using logistic regression after controlling for confounders (GWAS statistical significance threshold, P \< 5.00\*E-08)
次要结局
- Finding of SNPs associated with the risk of severe NTM lung disease compared with mild NTM lung disease(Baseline)
- Finding of SNPs associated with the risk of severe NTM lung disease compared with controls(Baseline)
- Finding of SNPs associated with the risk of Mycobacterium avium complex lung disease versus M. abscessus lung disease versus controls(Baseline)
研究者
Jae-Joon Yim
Professor
Seoul National University Hospital