Stem cell therapy for infertile women with diminished ovarian reserve (DOR)

Phase 1

Recruiting

Conditions: Diminished Ovarian Reserve(DOR).
Ovarian dysfunction, unspecified
E28.9

Registration Number: IRCT20231230060569N1

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 40

Inclusion Criteria

Female 20 to 45 years old with DOR
having a history of infertility for more than a year
Rejecting IVF at least once
The total number of antral follicles is less than 7 in two ovaries or the serum level of Anti Müllerin hormone is less than 1.1 ng/ml.
Having a low egg count or low-quality embryos in an IVF cycle
Absence of ovulation or amenorrhea that did not occur for at least three months before entering the study.

Exclusion Criteria

Pregnant people
IgA deficiency (before or now)
Secondary ovarian failure caused by sex chromosomes.
Taking anticoagulants
History of mental illnesses with drug addiction
Surgery leading to pelvic adhesions.
Malignancy or chronic pelvic pain
Infertility caused by strong male factor.
Dissatisfaction with the intervention
Abnormal uterine shape and endometrium caused by abscess.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anti Mullerian hormone. Timepoint: 2 weeks before and after injection. Method of measurement: ELISA KIT.;Antral Follicle Count(AFC). Timepoint: 2 weeks before and after injection. Method of measurement: ELISA KIT.;Estradiol. Timepoint: 2 weeks before and after injection. Method of measurement: ELISA KIT.;FSH. Timepoint: 2 weeks before and after injection. Method of measurement: ELISA KIT.

Secondary Outcome Measures

Name	Time	Method
Pregnancy success rate. Timepoint: after delivery. Method of measurement: Observation.;Embryo quality. Timepoint: 3 days after conception. Method of measurement: Microscope.