Personalizing Multifocal Transcranial Direct Stimulation Dose to Target the Motor Network in Older Adults
概览
- 阶段
- 不适用
- 干预措施
- Functional Magnetic Resonance Imaging (fMRI)
- 疾病 / 适应症
- Healthy
- 发起方
- University of Michigan
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Percentage change in the time to complete the nine-hole peg test (9-HPT)
- 状态
- 招募中
- 最后更新
- 2个月前
概览
简要总结
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
详细描述
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
研究者
Michael Vesia, PhD
Assistant Professor of Kinesiology
University of Michigan
入排标准
入选标准
- •Participants should be in good health with normal or corrected-to-normal visual acuity
- •Right handed
- •No history of neurological disorder
- •English speaker
- •Able to provide written consent prior to admission
排除标准
- •Left-handed
- •Participants are pregnant, suspect pregnancy or are attempting to become pregnant
- •Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump
- •Have cochlear hearing implants
- •Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol)
- •Have non removable body piercings or have foreign objects in body
- •Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol)
- •Have a personal or family history of seizure/epilepsy
- •Taking prescription drugs that lower the threshold for seizures
- •Recent history of excessive alcohol consumption
研究组 & 干预措施
HD-tDCS with standard intervention
Participants will have three daily sessions.
干预措施: Functional Magnetic Resonance Imaging (fMRI)
HD-tDCS with standard intervention
Participants will have three daily sessions.
干预措施: Standard HD-tDCS intervention
Personalized dose-controlled multifocal network-targeted HD-tDCS.
Participants will have three daily sessions.
干预措施: Multifocal network targeted HD-tDCS intervention
Personalized dose-controlled multifocal network-targeted HD-tDCS.
Participants will have three daily sessions.
干预措施: Functional Magnetic Resonance Imaging (fMRI)
结局指标
主要结局
Percentage change in the time to complete the nine-hole peg test (9-HPT)
时间窗: Baseline and 24 hours after the third sessions are completed
9-hole peg test is a manual dexterity measure, estimated as the time required to complete the task (seconds).
Percent change in precision force-tracking task
时间窗: Baseline and 24 hours after the third sessions are completed
Squared distance (error) from the cursor to the target in precision force-tracking task, estimated as the root mean squared error (RMSE).
次要结局
- Percentage change in the mean choice reaction time(Baseline and 24 hours after the third sessions are completed)