Coronary angiography after cardiac arrest

Recruiting

Conditions: cardiac arrest
10011082

Registration Number: NL-OMON50572

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 552

Inclusion Criteria

Age > 18
Comatose patients (Glasgow coma score < 8) with ROSC after OHCA
Ventricular tachycardia or ventricular fibrillation as initial arrest rhythm
Without signs of STEMI.

Exclusion Criteria

Signs of STEMI on the ECG at the emergency department (including new LBTB or
isolated ST depression in V1-V3 due to an true posterior infarct).
Hemodynamic instability unresponsive to medical therapy (defined as a systolic
blood pressure < 90 mm Hg).
An obvious or suspected non cardiac aetiology of the cardiac arrest.
A known severe renal dysfunction. (GRF< 30 ml/min)
Obvious or suspected pregnancy
Suspected or confirmed acute intracranial bleeding
Suspected or confirmed acute stroke
Known limitations in therapy or DO Not Resuscitate-order.
Known pre-arrest Cerebral Performance Category 3 or 4
>4 hours (240 min from ROSC to screening
Known inability to complete 90 day follow up

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary end point of the study is 90-days survival</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are 90-days survival with good, minor or moderate<br /><br>disability, myocardial injury measured by troponine and CK MB as area under the<br /><br>curve, occurrence off acute kidney injury, need for renal replacement therapy,<br /><br>time to target hypothermia, neurological status at ICU discharge and duration<br /><br>of inotropic support, left ventricular function on cardiac ultrasound or MRI<br /><br>(if available), functional performance measured with the RAND 36 questionnaire<br /><br>at 1 year and MACE and survival at 1 and 5 years.</p><br>