Effect of sodium bicarbonate supplementation on nutritional status in patients with kidney disease

Not Applicable

Completed

• Conditions: Health Condition 1: N189- Chronic kidney disease, unspecified

• Registration Number: CTRI/2015/09/006161
• Lead Sponsor: JIPMER

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2016-12-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 188

Inclusion Criteria

•Venous HCO3 less than 22 mEq/dl

•Renal Function: 15 ml/min/1.73m2 - 59 ml/min/1.73m2(Both values inclusive)

•Stable renal function for at least one month (less than 5 % fluctuations in GFR).

Exclusion Criteria

•Patients who had received bicarbonate therapy for more than two weeks duration in the preceding 6 months

•Patients on hemodialysis

•Structural and functional anomalies of Gastrointestinal tract

•Decompensated chronic liver disease

•Malignancy

•Morbid obesity (BMI >40 kg/m2),

•Immunosuppressive therapy of any kind

•Uncontrolled diabetes mellitus (FBS > 250 mg/dl)

•Overt congestive heart failure

•Presence of chronic infections

•HIV infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Change in nutrtitional status (assessed by anthropometric parameters, albumin,cholestrol and body fat percentage <br/ ><br>2. Change in inflammatory biomarkers (IL-1β & TNF-α) <br/ ><br>Timepoint: At enrollment <br/ ><br>Six months post enrollment <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Changes in glomerular filtration rateTimepoint: 6 months