Comparison between Dexmedetomidine and Magnesium sulphate for heart rate, blood pressure,intra-operative bleeding in functional endoscopic sinus surgery

Completed

Conditions: Nasal polyp, unspecified,

Registration Number: CTRI/2019/11/021910

Lead Sponsor: SMS Medical College Jaipur

Brief Summary: With this background, this study is designed to compare the effectiveness and safety of dexmedetomidine versus magnesium sulphate as a hypotensive agent in functional endoscopic sinus surgery with attention on the quality of surgical field, emergence time, sedation score, VAS score, recovery profile and to evaluate the side effects.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 60

Inclusion Criteria

body weight of 45 to 65 kg ASA grade 1 and 2 undergoing elective resection of nasal polyp (duration 60-70 minutes).

Exclusion Criteria

history of allergy to these drugs patients with pre existing bleeding and coagulation abnormalities history of hypertension, CAD, renal and hepatic dysfunction cerebral insufficiency patients not willing to participate in study orbital abscess CSF leak with or without CSF rhinorrhea.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
intraoperative SBP, DBP,MAP, HR	base line \| after loading of study drug \| after induction \| 1 min after intubation \| 5 min after intubation \| 10 min \| 20 min \| 30 min \| 40 min \| 50 min \| 60 min \| 70 min

Secondary Outcome Measures

Name	Time	Method
ASSESMENT OF INTRAOPERATIVE BLEEDING BY SURGEON	EMERGENCE TIME

Trial Locations

Locations (1): SMS hospital Jaipur
🇮🇳
Jaipur, RAJASTHAN, India
SMS hospital Jaipur
🇮🇳Jaipur, RAJASTHAN, India
Dr Jahnu Bhoj Nagal
Principal investigator
9461472545
nagaljahnu@gmail.com