to observe changes in Internal carotid artery and optic nerve sheath diameter after induction of general anaestheisa, carbon dioxide insufllation and head up tilt in patients undergoing laparoscopic cholecystectomy under general anaesthesia to predict and prevent changes in Intra-cranial pressure.

Not Applicable

• Conditions: Health Condition 1: K802- Calculus of gallbladder without cholecystitis

• Registration Number: CTRI/2022/04/041974
• Lead Sponsor: Mahtma Gandhi Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 May 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Consenting patients of either sex undergoing elective laparoscopic Cholecystectomy under general anaesthesia.

2. Age 18-60 yrs.

3. Non obese patients (BMI equal to or less than 32kg/m2).

4. Patient belonging to physical status ASA grade I/II.

Exclusion Criteria

1. Patients falling in criteria but not giving consent to participate in the study.

2. ASA grade III/IV/V.

3. Patient with hyperlipidaemia, known coronary artery disease, hypertension, cerebrovascular disease, diabetes mellitus, Patients on beta blockers or on statin therapy.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To derive and study changes in internal carotid artery blood flow ultrasonographically in patients undergoing elective laparoscopic cholecystectomy under general anaesthesia in terms of internal carotid artery diameter, internal carotid artery velocityTimepoint: 1. before induction of anaesthesia <br/ ><br>2. 2 minutes after induction of anaesthesia <br/ ><br>3. 2 minutes after creation of pneumoperitoneum <br/ ><br>4. 2 minutes after head-up tilt

Secondary Outcome Measures

Name	Time	Method
1- To relate these changes with changes in Optic nerve sheath diameter (ONSD). <br/ ><br>2- To relate these changes in internal carotid artery blood flow to mean arterial pressure, end tidal carbon dioxide (EtCO2). <br/ ><br>Timepoint: 1- Awake - just before induction of anaesthesia. <br/ ><br>2- Two minutes after induction of anaesthesia, <br/ ><br>3- Two minutes after creation of pneumoperitoneum and <br/ ><br>4- Two minutes after providing head up tilt <br/ ><br>