The efficacy of droxidopa fot the patients with MAPT mutation and PSP evaluated by tau imaging.
Not Applicable
Recruiting
- Conditions
- The patients with frontotemporal dementia harboring MAPT N279K and progressive supranuclear palsy-Richardson type.
- Registration Number
- JPRN-UMIN000030527
- Lead Sponsor
- Juntendo University School of Medicine
- Brief Summary
We examined tau-imaging for 14 patients with sporadic PSP and one patient with MAPT N279K. The results partially showed the spreading and increased accumulation of tau protein. Our sequential examinations confirmed the increased tau protein in vivo.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Exclude the patients not defined the above criteria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PBB3-PET, basic examinations of blood, urine, and cerebrospinal fluids. Metabolome, cognitive test, brain MRI, and SPECT.
- Secondary Outcome Measures
Name Time Method