Characterisation of chylomicron size distribution in subjects with metabolic syndrome: The effect of dietary fatty acid composition.

Not Applicable

• Conditions: Metabolic syndrome; Metabolic and Endocrine - Metabolic disorders

• Registration Number: ACTRN12614000352606
• Lead Sponsor: Curtin University, School of Public Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-04-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

must have abdominal obesity (waist circumference for males equal to or greater than 94 cm and females equal to or greater than 80 cm) and raised triglycerides (fasting TAG equal to or greater than 1.7 mmol/L) and one of the following factors: reduced serum HDL cholesterol less than 1.03 mmol/L in males and less than 1.29/L in females; impaired fasting glycemia (fasting plasma glucose equal to or greater than 5.6 mmol/L; or raised BP systolic equal to or greater than 130 mmHg or diastolic equal to or greater than 85 mmHg. The control group will be lean normolipidemic gender- and age-matched controls.

Exclusion Criteria

pregnant, in lactation, smoking, excess alcohol intake (greater than 2 Australian standard drink/day), use of lipid lowering medication, prior cardiovascular, hepatic or renal disease, greater than +/- 5 kg changes in the previous 6 months, have intention for losing weight in the next 6 months, on a dietary advice, taking dietary supplements (e.g. fish oil), history or current use of glucocorticosteroids, insulin and/or thiazolidinediones, or gastric disturbances.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Apolipoprotein B-48 response in plasma, chylomicron fraction, VLDL fraction and denser fraction. Area and incremental area under curve (AUC and IAUC) will be calculated using the trapezoidal rule (Matthews, 1988). Differences in postprandial responses between different test meals and between groups will be analysed by using repeated measures ANOVA within-between group factors with interaction. The detection of significant pairwise interactions will be done using the Bonferroni post hoc test. A p value less than 0.05 will be considered significant.[Baseline, at 2, 4, 6 and 8 hours after the test meal.]