The REACT (retirement in action) study

Not Applicable

Completed

• Conditions: Specialty: Primary Care, Primary sub-specialty: Ageing; Signs and Symptoms; Mobility-related disability

• Registration Number: ISRCTN45627165
• Lead Sponsor: niversity of Bath

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29665854 protocol 2022 Results article in https://doi.org/10.1016/S2468-2667(22)00004-4 (added 22/03/2022) 2022 Results article in https://doi.org/10.1016/S2468-2667(22)00030-5 Cost-effectiveness (added 22/03/2022) 2023 Results article in https://doi.org/10.1186/s12966-023-01434-0 Qualitative results (added 27/04/2023) 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/37299849/ Validation of the pfSTEP digital biomarker (added 11/07/2024) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/35361556/ MRI sub study results (added 11/07/2024) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35658857/ delivery fidelity of the intervention part of the process eveluation (added 11/07/2024) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37575112/ long-term functionality (added 11/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06-13
• Study Completion: 2020-05-31
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 777

Inclusion Criteria

1. Retired men and women aged 65 or older
2. Plan to reside in the target area (Bath/Bristol, Devon, Birmingham) for at least 24 months
3. Score 48 (inclusive) on the Short Physical Performance Battery (SPPB)

Exclusion Criteria

1. A documented or patient reported medical condition that would preclude participation, including:
1.1. Arthritis so severe it would prevent participation in physical activity
1.2. Parkinson’s disease
1.3. Dementia
1.4. Lung disease requiring use of corticosteroids or supplemental oxygen
1.5. Severe kidney disease that requires dialysis
1.6. Severe heart disease that would prevent participation in physical activity (for example chest pain when walking one or two hundred yards or up a flight of stairs)
1.7. An implanted cardiac defibrillator, a cardiac arrest which required resuscitation
1.8. Severe uncontrolled psychiatric illness
1.9. Currently receiving radiation therapy or chemotherapy treatment for cancer
1.10. Awaiting knee or hip surgery
1.11. Major heart surgery (including valve replacement or bypass surgery) or spinal surgery in the last six months
1.12. Any other clinical condition that their GP or clinician considers would make them unsuitable for participation in a physical activity rehabilitation programme to prevent decline of lower limb functioning
2. Self-reported inability to walk across a room or the need for a walker or the help of another person
3. Existing major mobility limitation.
4. Being unable to complete the 4m walk component of SPPB
5. Current involvement in other regular (at least weekly) exercise programmes that aim to build lower limb capacity or fitness (e.g. walking programmes)
6. Living in residential or nursing care
7. Another member of the household participating in REACT

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional performance is measured using the Short Physical Performance Battery (SPPB) score at baseline, 6, 12 and 24 months.