se of zinc and magnesium as a supplement to non-surgical periodontal treatment in patients with type 2 diabetes mellitus
Not Applicable
Completed
- Conditions
- Treatment for periodontal diseases in type 2 diabates patientsOral Health
- Registration Number
- ISRCTN14092381
- Lead Sponsor
- niversidad Veracruzana
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 39
Inclusion Criteria
1. Patients with periodontal diseases associated with type 2 diabetes mellitus
2. Males and females
3. Aged 18-60 years
4. Accepted to participate in the research
5. Patients under medical surveillance
6. Patients who attended the periodontia service at an established time period
Exclusion Criteria
1 Patients with hypersensitive to zinc and magnesium supplements
2. Patients with prior non-surgical periodontal treatment
3. Patients who consumed antibiotics, steroids, and central nervous system (CNS) depressants
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Clinical periodontal parameters such as deep on probing, clinical attachment level, bleeding on probing, and periodontal inflamed surface area, measured using periodontogram at baseline and 30 days after treatment<br> 2. Biochemical parameters such as glucose levels, zinc levels, magnesium levels, total cholesterol levels, triglycerides levels, HDL-C, and LDL-C, measured using biochemical analyses at baseline and 30 days after non-surgical periodontal treatment<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Oxidative stress measured using lipoperoxidation reaction and MDA levels at baseline (day 0) and 30 days after the interventions<br> 2. Antioxidant enzymes measured using commercial kits (superoxide dismutase and catalase levels) at baseline (day 0) and 30 days after the interventions<br>