Personalized Parkinson Project - Progressive Supranuclear Palsy cohort

Completed

Conditions: Progressive Supranuclear Palsy
10028037

Registration Number: NL-OMON49320

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

* Subject has possible or probable PSP, according to the established
international criteria defined by the Movement Disorders Society (MDS-PSP
criteria, Höglinger et al, 2017); diagnosis is confirmed based on by consensus
review of a videotaped neurological examination by two neurologists with deep
expertise in movement disorders. In case the experts still have doubts, the
treating physician will be asked to confirm the diagnosis and to send an MRI.
If that additional information does not take away doubts about the diagnosis,
the participant will be excluded.
* Subject is an adult, at least 50 years of age.
* Subject can read and understand Dutch.
* Subject has completed the CMO-approved Informed Consent.
* Subject is willing, competent, and able to comply with all aspects of the
protocol.
* Subject is able to walk at least 5 steps with or without minimal assistance
(ie, stabilization of 1 arm or use of a cane or walker).

Exclusion Criteria

* Subject has an additional condition or situation that, in the opinion of the
Investigator, makes the subject inappropriate for participation in the study.
* For Study Watch: subject is allergic to nickel.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective is to develop algorithms for the detection of disease<br /><br>progression in PSP patients in key clinical parameters: bradykinesia, gait,<br /><br>rising from a chair and falls, based on (1) sensor data obtained by means of<br /><br>passive monitoring during daily living; and (2) sensor data collected during<br /><br>the Virtual Motor Exam.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The second objective of this study is to create a longitudinal dataset<br />describing the clinical and functional characteristics of a representative PSP<br />cohort to allow researchers to investigate important unanswered questions in<br />PSP.</p>