Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Phase 4
Withdrawn
- Conditions
- Infertility
- Interventions
- Biological: PXN sperm treatmentBiological: Sperm activation with PXN and oocyte activation
- Registration Number
- NCT02051075
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Women up to 35 years of age
- immotile sperm
- At least 6 mature eggs
Exclusion Criteria
- globozoospermia
- "Freeze all" cycles because of OHSS risk.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PXN only PXN sperm treatment Sperm activation with PXN before ICSI PXN activation and oocyte activation Sperm activation with PXN and oocyte activation Sperm activation with PXN and oocyte activation
- Primary Outcome Measures
Name Time Method Clinical pregnancy One month post oocyte retrieval Demonstration of fetal heart activity 1 month post oocyte retrieval.
- Secondary Outcome Measures
Name Time Method Fertilization rate One day post oocyte retrieval Normal, 2 pronuclei, zygote one day post ICSI
Trial Locations
- Locations (1)
Rambam medical Center
🇮🇱Haifa, Israel