Analgesic Use for Pain Relief in Scorpion Sting

Not Applicable

Completed

• Conditions: Scorpion Stings
• Interventions: Drug: Lidocaine topical; Drug: Dexketoprofen Trometamol; Drug: Placebo; Drug: paracetamol

• Registration Number: NCT05125796
• Lead Sponsor: Adiyaman University Research Hospital

Brief Summary

In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.

Detailed Description

Aim: In this study, the analgesic efficacy of intravenous (IV) paracetamol, IV dexketoprofen trometamol and topical lidocaine will be compared in patients presenting with pain after scorpion sting.

Methods: This study is a double-blind, randomized, placebo-controlled study conducted in a tertiary emergency department. Adult patients who applied to the study with no systemic findings after scorpion sting and especially with pain will be randomly assigned to one of 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine or placebo. In order to determine the intensity of pain, Visual Analog Pain Score (VAS) will be measured at the time of admission to the emergency department, at the 30th minute and at the 60th minute. Afterwards, the VAS score changes between the groups will be compared.

Study Timeline

• Study Start: 2020-09-01
• Primary Completion: 2021-10-01
• Study Completion: 2021-10-01
• Study First Submitted: 2021-11-02
• Study First Submitted QC: 2021-11-08
• Study First Posted: 2021-11-18
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-07
• Last Update Posted: 2024-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• Patients aged 18 and over
• Scorpion sting with pain
• The diagnostic criteria of Grade 1 for Scorpion sting

Exclusion Criteria

• Patients who denied to give informed consent
• Taking analgesic treatment (ice application or drugs etc.) in the last 6 hours
• Any symptoms and findings of systemic toxicity of scorpion sting
• Pregnant women
• Hemodynamically unstable patients
• Known allergy to drugs of the study
• Patients with renal disease
• The cases that passed more than 6 hours after the bite

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
topical lidocaine	Lidocaine topical	%5 lidocaine 5 gr topical
Dexketoprofen Trometamol	Dexketoprofen Trometamol	50 mg intravenous Dexketoprofen Trometamol
placebo	Placebo	100 mL intravenous normal saline+ placebo topical pomade
paracetamol	paracetamol	1000 mg intravenous paracetamol

Primary Outcome Measures

Name	Time	Method
Change of the intensity of pain	30 minutes and 60 minutes after the study drug administered	Pain intense will be measured by 100 mm visual analog scale (Zero; no pain and 100 mm; the worst pain) after 30th and 60th minutes later after the study drug administered

Secondary Outcome Measures

Name	Time	Method
Adverse events	60 minutes after the study drug administered	60 minutes after the study drug administered
need to rescue medication	60 minutes after the study drug administered	60 minutes after the study drug administered

Trial Locations

Locations (1)

Adiyaman University Research Hospital; 🇹🇷 Adıyaman, Central, Turkey