Prone Breast Radiotherapy Treatment Planning Observational Study

Active, not recruiting

• Conditions: Breast Cancer Female
• Interventions: Radiation: Prone and supine simulation

• Registration Number: NCT02237469
• Lead Sponsor: Vincent Vinh-Hung

Brief Summary

The study purpose is to evaluate whether or not clinical characteristics of women with breast cancer can predict which position for radiation treatment, prone or supine, will be associated with a dosimetry gain. Dosimetry gain in this study means the lowest radiation dose to non-target organs (heart, lungs, contralateral breast), while giving the prescribed dose to tumor bed and ipsilateral breast.

Detailed Description

Retrospectively identify women who received curative radiation treatment after breast conserving cancer surgery, in whom simulation in prone and in supine position was performed. Compare the treatment plans for doses to targets and to non-target organs, according to clinical parameters of body mass index, size of breast, location of tumor and side. Furthermore, evaluate whether a single CT slide is enough or not to predict a dosimetry advantage.

Study Timeline

• Study Start: 2010-09
• Primary Completion: 2013-04
• Study First Submitted: 2014-09-07
• Study First Submitted QC: 2014-09-09
• Study First Posted: 2014-09-11
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-18
• Last Update Posted: 2022-12-21
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Female
• Target Recruitment: 280

Inclusion Criteria

• Breast conserving surgery
• Adjuvant radiation treatment
• Simulation done prone and supine

Exclusion Criteria

• Simulation in only one position

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prone and supine simulation	Prone and supine simulation	Women with breast cancer receiving simulation in prone and in supine position for adjuvant radiation treatment.

Primary Outcome Measures

Name	Time	Method
Radiation dose to heart and lungs	4 months	Computations of doses and verification of physics charts.

Secondary Outcome Measures

Name	Time	Method
Radiation dose to tumor bed and ipsilateral breast	4 months	Computations of doses and verification of physics charts.

Trial Locations

Locations (1)

Geneva University Hospitals; 🇨🇭 Geneva, Switzerland