Prognostic Value of Cardiovascular Risk of Soluble Suppression of Tumorigenesis-2 and High Sensitivity Troponin I in Patients With Acute Chest Pain
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Evaluate sST2 predictive value's
研究概览
简要总结
The role of the sST2 biomarker has been widely explored in heart failure, so much so that it was included in the AHA guidelines in 2013 and 2017. Recently, several studies are proposing a role of sST2 in the prognostic stratification of patients with Acute Coronary Syndrome and ischemic heart disease, in association with other biomarkers even proposing a possible therapeutic differentiation. The combined use of sST2 with high-sensitivity troponins could be a promising strategy to identify those patients who, despite having early rule-out after evaluation at the Emergency Department, have a higher risk of onset of cardiovascular events in the medium-long term.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years;
- •Chest pain of presumable cardiac origin and uncertain etiological diagnosis
- •ECG not diagnostic for ischemia
- •troponin values within normal ranges
排除标准
- •STEMI myocardial infarction
- •Sepsis and viral infections
- •Patients with ECG abnormalities that make it uninterpretable for ischemic purposes
- •Patients with previous coronary events
- •History of heart failure
- •Known diagnosis of cardiovascular disease, acute or chronic, including pericarditis, myocarditis
- •Conditions involving sST2 elevations unrelated to cardiac causes, particularly acute/chronic inflammatory or fibrotic conditions (inflammatory bowel disease, malignancy, moderate to severe pulmonary fibrosis, chronic liver disease; autoimmune disorders)
结局指标
主要结局
Evaluate sST2 predictive value's
时间窗: 24 months
Evaluate the medium-long term (1 year) predictive value of the sST2 biomarker in the heart patients attending at the Emergency Department for non-STEMI Acute Chest Pain.
次要结局
- Create a multiparametric algorithm/score(36 months)
- Compare sST2 prognostic value with troponins(24 months)
研究者
Baroni Silvia
Confirmed researcher - Adjunct Professor-M.D.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS