Administration of Ketamine to Branchial Plexus Block Using Axillary Approach : Comparative Study
试验速览
- 阶段
- 不适用
- 入组人数
- 81
- 试验地点
- 1
- 主要终点
- VAS (Visual Analog Scale) over 24 hours following intervention
研究概览
简要总结
The purpose of this study is to assess Ketamine as an adjuvant to Branchial Plexus Blockade.
详细描述
After being informed about the study, patients giving written informed consent will undergo anaesthesia using the Ultrasound Guided Axillary Approach to Brachial Plexus Blockade, in order to undergo forearm surgery. The purpose of this study is to assess whether Ketamine as an adjuvant lengthens sensory and motor blockade and whether it has an effect on "rebound pain" when the anaesthetic effect fades. Therefore the study will compare intravenous, regional and no administration of Ketamine as an adjuvant to Branchial Plexus Blockade. Patients will be asked to fill in a Pain VAS (Visual Analog Scale) for 24 hours following the intervention, in order to assess effectiveness of each anaesthetic method. Side effects, onset time, motor blockade score and rescue dose are also recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI 20-35
- •ASA score I, II, III
排除标准
- •Mental disorder
- •Peripheral neuropathy
- •Severe hepatic or renal disease
- •Gastrointestinal bleeding history
研究组 & 干预措施
Control
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,without Ketamine as an adjuvant.
干预措施: Forearm surgey (Procedure)
Control
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,without Ketamine as an adjuvant.
干预措施: Ropivacaine (Drug)
Ketamine IV
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg intravenously.
干预措施: Forearm surgey (Procedure)
Ketamine IV
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg intravenously.
干预措施: Ropivacaine (Drug)
Ketamine IV
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg intravenously.
干预措施: Ketamine (Drug)
Ketamine Regional
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg regionally.
干预措施: Forearm surgey (Procedure)
Ketamine Regional
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg regionally.
干预措施: Ropivacaine (Drug)
Ketamine Regional
Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg regionally.
干预措施: Ketamine (Drug)
结局指标
主要结局
VAS (Visual Analog Scale) over 24 hours following intervention
时间窗: 24 hours
VAS scale is expressed in integer numbers ranging from 0-10, where 0=no pain, 10= excruciating pain.
次要结局
- Motor Blockade Score(24 hours)
- Side Effects(24 hours)
- Anesthesia Onset time(24 hours)
- Rescue Dose(24 hours)
研究者
Demetra Solomou
Anaesthesiology Resident at KAT and Masters Student at National and Kapodistrian University of Athens
National and Kapodistrian University of Athens