Identification of Biomarkers for Obstructive Sleep Apnoea Syndrome
- Conditions
- Obstructive Sleep Apnoea Syndrome
- Registration Number
- NCT02043483
- Lead Sponsor
- Universidade Nova de Lisboa
- Brief Summary
Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus). Until now, no molecular markers for this physiopathological connection have been identified.
This project aims to determine non-invasive biomarkers that may allow better comprehension of the metabolic consequences of OSAS, as well as assess the effect of Continuous positive airway pressure (CPAP) on these metabolic parameters.
This project will integrate the clinical, metabolic, genetic/proteomic and biologic systems to further explore the mechanisms behind OSAS, as well as the effect of the treatment with CPAP.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 120
- Male
- 25-60 years
- Mild/Moderate/Severe OSAS
- Female
- Other sleep disorders
- Previous CPAP therapy
- Type 1 diabetes mellitus
- Familiar Dyslipidemia
- Severe organ pathology
- Acute disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of patients with clinical improvement 6 months Treatment efficacy of CPAP will be assessed at the end of treatment through a clinical observation.
- Secondary Outcome Measures
Name Time Method Frequency of occurence of biomarkers 6 months Using Mass Spectrometric Immunoassay, we will identify which biomarkers have a positive association with long-term treatment effect.
Trial Locations
- Locations (1)
Centro Hospitalar Lisboa Norte
🇵🇹Lisbon, Portugal