The Diaphragm Activity Level and Cardiopulmonary Function Between Heated Humidified High-Flow Nasal Cannula and Unheated Humidified High-Flow Oxygen Mask in Acute Exacerbation of COPD Patients as Post-Extubation Respiratory Support
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Diaphragm electrical activity
研究概览
简要总结
Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support. Studies indicate that HHHFNC has seminar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. There are no clinical data of diaphragm electrical activity and cardiopulmonary function for using HHHFNC and UHFOM as post-extubation respiratory support.
详细描述
Objectives： The aim of this study is to compare the Edi level and cardiopulmonary parameters between heated humidified high-flow nasal cannula (HHHFNC) versus unheated high-flow oxygen mask (UHFOM) in acute exacerbation of chronic obstructive pulmonary disease (COPD) patients with post-extubation respiratory support. This is the first clinical trial to investigate and analysis the variations of cardiopulmonary parameters and Edi level between HHHFNC and UHFOM in adult patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
盲法说明
All data will be decoded before biostatics analysis
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AE of COPD received intubation and ready to be weaning
- •P/F ratio > 200 during SBT before extubation
排除标准
- •Unable to insert NG tube
- •Refuse to re-intubated when respiratory failure after extubation
- •Planned NIV use after extubation
结局指标
主要结局
Diaphragm electrical activity
时间窗: 2 days
In voltage
次要结局
- Cardiac index(2 days)
- PtcO2 & PtcCO2(2 days)
- Re-intubation rate(2 days)
- ICU stay(through study completion, an average 1 months)
- Hospital stay(through study completion, an average 3 months)
研究者
Ke-Yun, Chao
Group leader of Respiratory Therapists
Fu Jen Catholic University