The Diaphragm Activity Level and Cardiopulmonary Function Between Heated Humidified High-Flow Nasal Cannula and Unheated Humidified High-Flow Oxygen Mask in Acute Exacerbation of COPD Patients as Post-Extubation Respiratory Support
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Lung Disease
- Sponsor
- Fu Jen Catholic University
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Diaphragm electrical activity
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support. Studies indicate that HHHFNC has seminar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. There are no clinical data of diaphragm electrical activity and cardiopulmonary function for using HHHFNC and UHFOM as post-extubation respiratory support.
Detailed Description
Objectives： The aim of this study is to compare the Edi level and cardiopulmonary parameters between heated humidified high-flow nasal cannula (HHHFNC) versus unheated high-flow oxygen mask (UHFOM) in acute exacerbation of chronic obstructive pulmonary disease (COPD) patients with post-extubation respiratory support. This is the first clinical trial to investigate and analysis the variations of cardiopulmonary parameters and Edi level between HHHFNC and UHFOM in adult patients.
Investigators
Ke-Yun, Chao
Group leader of Respiratory Therapists
Fu Jen Catholic University
Eligibility Criteria
Inclusion Criteria
- •AE of COPD received intubation and ready to be weaning
- •P/F ratio \> 200 during SBT before extubation
Exclusion Criteria
- •Unable to insert NG tube
- •Refuse to re-intubated when respiratory failure after extubation
- •Planned NIV use after extubation
Outcomes
Primary Outcomes
Diaphragm electrical activity
Time Frame: 2 days
In voltage
Secondary Outcomes
- Cardiac index(2 days)
- PtcO2 & PtcCO2(2 days)
- Re-intubation rate(2 days)
- ICU stay(through study completion, an average 1 months)
- Hospital stay(through study completion, an average 3 months)