Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 348
- 试验地点
- 2
- 主要终点
- mechanical ventilation duration
研究概览
简要总结
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU. SBTs are tests used to determine if a patient is ready to breathe on their own without the help of a ventilator. The study will compare two different timing strategies for these trials: one group of patients will have the test early in the morning, while the other group will have it later in the morning. By observing the outcomes, such as how long patients need to stay on the ventilator, the study hopes to find the best time to perform these trials to help patients recover more quickly and safely.
详细描述
This study seeks to understand how the timing of Spontaneous Breathing Trials (SBTs) impacts the recovery of adult patients who are on mechanical ventilation in the Intensive Care Unit (ICU). Mechanical ventilation is a life-support technique used for patients who are unable to breathe on their own. The Spontaneous Breathing Trial is a key step in assessing whether a patient is ready to breathe independently and can safely have the ventilator removed.
Currently, there is no universal standard for the best time of day to conduct these trials. Some hospitals perform SBTs early in the morning, while others wait until later in the morning when more staff are available. This study will compare two groups of patients: one group will have their SBTs early in the morning, and the other group will have them later.
The primary goal is to determine whether the timing of these trials affects how long patients need mechanical ventilation, how quickly they can be safely extubated (removal of the breathing tube), and overall recovery outcomes, such as ICU stay and hospital discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 21 years or older.
- •Patients who have been on mechanical ventilation for more than 48 hours.
- •Patients who have completed at least one SBT.
排除标准
- •Patients intubated at other hospitals.
- •Patients intubated for surgical or interventional procedures.
- •Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).
- •Patients with a tracheostomy.
结局指标
主要结局
mechanical ventilation duration
时间窗: From enrollment to the end of study at 28 days
The primary outcome of this study is the duration of mechanical ventilation, which refers to the total number of days a patient remains on a mechanical ventilator in the ICU. This measure begins from the moment a patient is initially placed on the ventilator and continues until the patient is successfully extubated (the breathing tube is removed) and can breathe independently without the need for ventilatory support.
次要结局
- ICU and Hospital Mortality(From enrollment to the end of study at 28 days)
- Duration Between SBT Success and Extubation(From enrollment to the end of study at 28 days)
- ICU and Hospital Lengths of Stay(From enrollment to the end of study at 28 days)
- Reintubation Rates(From enrollment to the end of study at 28 days)
- Tracheostomy Rates(From enrollment to the end of study at 28 days)
研究者
Jie Li
Professor
Rush University Medical Center