Study Effect of WHO Recommended Dose of Pralidoxime in the Treatment of Organophosphorus Poisoning
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- mortality rate
研究概览
简要总结
To evaluate the effectiveness of Pralidoxime, a drug used for treatment of pesticide poisoning (Organophosphorous poisonings)
详细描述
The present study was designed to critically analyze the role of pralidoxime in patients with moderate to severe poisoning by dividing them into two comparable groups in all aspects and using WHO recommended dose of pralidoxime (30mg/kg bolus I.V over 20 min followed by 8mg/kg/hr continuous infusion). This dose and continuous infusion protocol is more likely to maintain adequate blood concentrations of pralidoxime throughout 24 hours and thus would avoid any failures in effectiveness of pralidoxime because of inconsistent blood levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 14 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •history of alleged organophosphorus intake age > 14 years < 60 years clinical signs and symptoms of organophosphorus poisoning.
排除标准
- •< 14 years or > 60 years of age known pregnancy pralidoxime administration at the transferring hospital carbamate poisoning any chronic illnesses
- •≥ 12 hour interval from time of poisoning to initiation of treatment pre-hospital cardiac or respiratory arrest.
研究组 & 干预措施
Placebo
Placebo was given to compare the effects
干预措施: Pralidoxime (Drug)
Pralidoxime
Pralidoxime for treating organophosphorous poisoning patients
干预措施: Pralidoxime (Drug)
结局指标
主要结局
mortality rate
时间窗: upto one year
次要结局
- duration of ventilation(upto one year)
研究者
Tariq Wani
Registar
Sheri Kashmir Institute of Medical Sciences