Is the WHO Recommended Dose of Pralidoxime Effective in the Treatment of Organophosphorus Poisoning?
- Registration Number
- NCT02040350
- Lead Sponsor
- Sheri Kashmir Institute of Medical Sciences
- Brief Summary
To evaluate the effectiveness of Pralidoxime, a drug used for treatment of pesticide poisoning (Organophosphorous poisonings)
- Detailed Description
The present study was designed to critically analyze the role of pralidoxime in patients with moderate to severe poisoning by dividing them into two comparable groups in all aspects and using WHO recommended dose of pralidoxime (30mg/kg bolus I.V over 20 min followed by 8mg/kg/hr continuous infusion). This dose and continuous infusion protocol is more likely to maintain adequate blood concentrations of pralidoxime throughout 24 hours and thus would avoid any failures in effectiveness of pralidoxime because of inconsistent blood levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
history of alleged organophosphorus intake age > 14 years < 60 years clinical signs and symptoms of organophosphorus poisoning.
< 14 years or > 60 years of age known pregnancy pralidoxime administration at the transferring hospital carbamate poisoning any chronic illnesses
ā„ 12 hour interval from time of poisoning to initiation of treatment pre-hospital cardiac or respiratory arrest.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Placebo Pralidoxime Placebo was given to compare the effects Pralidoxime Pralidoxime Pralidoxime for treating organophosphorous poisoning patients
- Primary Outcome Measures
Name Time Method mortality rate upto one year
- Secondary Outcome Measures
Name Time Method duration of ventilation upto one year
Trial Locations
- Locations (1)
Sheri kashmir insititute of medical sciences
š®š³Srinagar, Srinagar Kashmir, India