Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- The Saving Inventory-Revised (SI-R) Total Score
研究概览
简要总结
This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.
详细描述
Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with hoarding disorder as primary disorder
- •Clinical Global Impression Score > 3
- •Saving Inventory-Revised score > 39
排除标准
- •Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
- •Severe and/or unstable medical or psychiatric condition that require immediate medical attention
- •Diagnosed with current major depressive episode
- •Currently taking psychiatric medication
结局指标
主要结局
The Saving Inventory-Revised (SI-R) Total Score
时间窗: Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up
The Saving Inventory-Revised (SI-R) is a self-report measure which includes 23 items assessing the severity of hoarding symptoms including difficulty discarding, acquiring, and clutter. The 23 items are added for a total score which ranges from 0 to 92 and with higher score indicating more severe hoarding symptoms.
次要结局
未报告次要终点