Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
- Conditions
- Hoarding
- Interventions
- Device: Neurostar Transcranial Magnetic Stimulation Therapy System
- Registration Number
- NCT02236767
- Lead Sponsor
- Hartford Hospital
- Brief Summary
This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.
- Detailed Description
Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
- Diagnosed with hoarding disorder as primary disorder
- Clinical Global Impression Score > 3
- Saving Inventory-Revised score > 39
- Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
- Severe and/or unstable medical or psychiatric condition that require immediate medical attention
- Diagnosed with current major depressive episode
- Currently taking psychiatric medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description rTMS Treatment Neurostar Transcranial Magnetic Stimulation Therapy System NeuroStar Transcranial Magnetic Stimulation Therapy System
- Primary Outcome Measures
Name Time Method The Saving Inventory-Revised (SI-R) Total Score Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up The Saving Inventory-Revised (SI-R) is a self-report measure which includes 23 items assessing the severity of hoarding symptoms including difficulty discarding, acquiring, and clutter. The 23 items are added for a total score which ranges from 0 to 92 and with higher score indicating more severe hoarding symptoms.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hartford Hospital
🇺🇸Hartford, Connecticut, United States