Identification of New Patient Stratification Tools in MSS RAS mt mCRC

Completed

• Conditions: Advanced Colorectal Cancer

• Registration Number: NCT03699111
• Lead Sponsor: Cancer Trials Ireland

Brief Summary

This is a translational, multicentre and multinational study. The aim of this study is to identify new patient stratification tools in microsatellite stable RAS mutant metastatic Colorectal Cancer

Detailed Description

The rational of COLOSSUS is to provide new and more effective stratification tools and therapeutic interventions, specifically tailored to MSS RAS mt mCRC patients

Study Timeline

• Study Start: 2018-09-19
• Study First Submitted: 2018-10-05
• Study First Submitted QC: 2018-10-05
• Study First Posted: 2018-10-09
• Primary Completion: 2022-04-01
• Study Completion: 2022-04-03
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-25
• Last Update Posted: 2022-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stratification Tools	4 years	Identification and technical (analytical) validation of new patient stratification tools (COLOSSUS subtypes) in MSS RAS mt mCRC using a novel integrative systems biomedicine multi-omics discovery framework.

Trial Locations

Locations (10)

Private Practice Oncology, Heidelberg; 🇩🇪 Heidelberg, Germany

University Hospital, Mannheim; 🇩🇪 Mannheim, Germany

Bon Secours Hospital, Cork; 🇮🇪 Cork, Ireland

Beaumont Hospital; 🇮🇪 Dublin, Ireland

St Vincent's University Hospital; 🇮🇪 Dublin, Ireland

University Hospital Galway; 🇮🇪 Galway, Ireland

Private Practice Oncology, Speyer; 🇩🇪 Speyer, Germany

Hospital Universitari Vall d'Hebron; 🇪🇸 Barcelona, Spain

Institut Catala d'Oncologia; 🇪🇸 Barcelona, Spain

Tallaght University Hospital; 🇮🇪 Dublin, Ireland