Observational study to evaluate the utility of confirmation of germline mutations in patients with solid tumors and relatives
Not Applicable
Recruiting
- Conditions
- Hereditary cancer
- Registration Number
- JPRN-UMIN000046085
- Lead Sponsor
- ational Cancer Center Hospital East
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 670
Inclusion Criteria
Not provided
Exclusion Criteria
1. The physician in charge determines that the research subject is unsuitable for enrollment in this study in light of the subject's physical or mental condition. 2. Patients has a history of bone marrow transplantation.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PGV identification rate based on PGPV in liquid biopsy and sensitivity and specificity for confirmation of PGV at different VAF cutoffs.
- Secondary Outcome Measures
Name Time Method 1. PGV identification rate based on PGPV in tumor tissue CGP and sensitivity and specificity for confirmation of PGV at different VAF cutoffs. 2. characteristics of the background of patients with confirmed PGPV in liquid biopsy 3. newly detected/confirmed PGV by MGP 4. usefulness of diagnosis for carriers in first-degree relatives of confirmed PGV patients