The Inflammatory Burden in Hemodialysis vs. Peritoneal Dialysis Patients: the Role of Alpha-defensin
Not Applicable
- Conditions
- Kidney FailureInflammation
- Registration Number
- NCT03845530
- Lead Sponsor
- Hillel Yaffe Medical Center
- Brief Summary
The aim of this study is to determine the levels of alpha-defensin throughout the hemodialysis course compared to the levels at the end of a course of peritoneal dialysis, as a reflection of the inflammatory burden.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Kidney failure patients undergoing hemodialysis or peritoneal dialysis
Exclusion Criteria
- Active inflammatory or infectious disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Alpha-Defensin Levels One year Alpha-defensin levels will be compared between the two arms
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link alpha-defensin to systemic inflammation in hemodialysis vs. peritoneal dialysis patients?
How does alpha-defensin measurement compare to traditional biomarkers like IL-6 or CRP in predicting dialysis-related inflammation?
What are the potential adverse events associated with elevated alpha-defensin levels in end-stage renal disease patients?
Can alpha-defensin serve as a biomarker for selecting dialysis modality in patients with chronic kidney disease and comorbid inflammation?
What anti-inflammatory therapies target defensin pathways in hemodialysis or peritoneal dialysis populations?
Trial Locations
- Locations (1)
Hillel Yaffe Medical Center
🇮🇱Hadera, Israel
Hillel Yaffe Medical Center🇮🇱Hadera, IsraelRami Abu Fanne, MD, PhDContactramia@hadassah.org.il