Homeopathic Treatment of Children Suffering From PFAPA

Completed

• Conditions: Periodic Fever Syndrome
• Interventions: Drug: Homeopathic Globule

• Registration Number: NCT05995288
• Lead Sponsor: Michael Frass

Brief Summary

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is frequently diagnosed in young children. Fevers recurring at a nearly predictable rate every three to eight weeks are the signature symptom of PFAPA syndrome. PFAPA is an acquired autoinflammatory disorder, which recurs in association with at least one sign of aphthous stomatitis, pharyngitis, and cervical lymph node enlargement. The aim of this retrospective case report is to gain an impression of the course of disease during individualized homeopathic treatment in children suffering from PFAPA.

Detailed Description

In this retrospective study, the investigators collected the history and symptoms of 13 consecutive PFAPA patients. The investigators also described the individually chosen homeopathic medicinal products (HMPs) used, as well as the course of the disease. Clinical outcome of case reports was assessed using the "Modified Naranjo Criteria for Homeopathy-Causal Attribution Inventory". Eight points are taken as the threshold for the possible correlation between homeopathic therapy and improvement of symptoms or cure in chronic cases

Study Timeline

• Study Start: 2019-05-01
• Primary Completion: 2020-12-31
• Status Verified: 2023-08
• Study Completion: 2023-08-08
• Study First Submitted: 2023-08-09
• Study First Submitted QC: 2023-08-09
• Last Update Submitted: 2023-08-15
• Study First Posted: 2023-08-16
• Last Update Posted: 2023-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

Children suffering from fever with at least one of the symptooms of PFAPA besides fever

Exclusion Criteria

Parents not willing to sign informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Children suffering from PFAPA	Homeopathic Globule	Children suffering from periodic fever, with at least one of the following symptoms: aphthous stomatitis, pharyngitis, cervical adenitis

Primary Outcome Measures

Name	Time	Method
Periodic fever flares	30 months	Appearance of periodic fever flares

Trial Locations

Locations (1)

Michael Frass; 🇦🇹 Wien, Austria