Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)

Phase 3

• Conditions: Embryonic Development; Pregnancy; VEGF
• Interventions: Drug: 10000 IU urinary HCG; Drug: 250 mcg recombinant HCG

• Registration Number: NCT00954265
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

To access whether the ovulation triggering with rec-HCG instead urinary-HCG has any impact on the blastulation rate and pregnancy rate of patients undergoing IVF treatment

Detailed Description

Not available

Study Timeline

• Study Start: 2005-08
• Primary Completion: 2007-12
• Status Verified: 2009-08
• Study First Submitted: 2009-08-06
• Study First Submitted QC: 2009-08-06
• Study First Posted: 2009-08-07
• Last Update Submitted: 2009-12-23
• Last Update Posted: 2009-12-24
• Study Completion: 2010-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 130

Inclusion Criteria

• FSH<12,
• normal sperm,less than 36y,
• single blastocyst transfer

Exclusion Criteria

• endometriosis stage 3&4,
• pco

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Urinary-HCG group	10000 IU urinary HCG	These patients received u-HCG for ovulation triggering during ovarian stimulation for IVF
Recombinant HCG group	250 mcg recombinant HCG	These patients received rec-HCG for ovulation triggering during ovarian stimulation for IVF

Primary Outcome Measures

Name	Time	Method
blastulation rate	on day-5

Secondary Outcome Measures

Name	Time	Method
pregnancy rates, VEGF levels, OHSS rate	14 days after oocyte pick up

Trial Locations

Locations (1)

Centre for Reproductive Medicine, UZ Brussel; 🇧🇪 Brussels, Jette, Belgium