Endometrial Advancement After Rec or u-HCG Triggering

Phase 4

Completed

• Conditions: Infertility
• Interventions: Drug: 10000 IU urinary HCG; Drug: 250 mcg recombinant HCG

• Registration Number: NCT00953628
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

The purpose of this study is to investigate any potential advantages of replacing human chorionic gonadotropin (uhCG) with recombinant human chorionic gonadotropin (recHCG) for final oocyte maturation with regard to Ovarian hyperstimulation syndrome (OHSS)pathophysiology, endometrium receptivity and embryo quality and clinical pregnancy.

Detailed Description

Biopsies of endometrium were taken in different groups Pregnancy rates were compared among defferent groups

Study Timeline

• Study Start: 2005-08
• Primary Completion: 2006-12
• Study Completion: 2008-12
• Study First Submitted: 2009-08-05
• Study First Submitted QC: 2009-08-05
• Study First Posted: 2009-08-06
• Status Verified: 2015-12
• Last Update Submitted: 2015-12-01
• Last Update Posted: 2015-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 130

Inclusion Criteria

• Less than 36 years old
• Male or tubal infertility
• FSH<12 on day 3

Exclusion Criteria

• Endometriosis stage 3 & 4

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
o Group A=uHCG ovul trig	10000 IU urinary HCG	HCG for triggering
o Group B=recHCG ovul trig	250 mcg recombinant HCG	recombinant HCG for triggering

Primary Outcome Measures

Name	Time	Method
endometrium histology on the day of OPU	day of oocytre pick up

Secondary Outcome Measures

Name	Time	Method
pregnancy rate	14 days after oocyte pick up

Trial Locations

Locations (1)

Centre for Reproductive Medicine, UZ Brussel; 🇧🇪 Brussels, Jette, Belgium