The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients

• Conditions: COPD

• Registration Number: NCT04051931
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

The pathophysiological characteristics of COPD is irreversible airflow restriction which may influence the gas exchange and cause the abnormal PaO2 and PaCO2. Assessment of the partial arterial pressure of carbon dioxide (PaCO2 ) is the 'gold standard' for the evaluation of the adequacy of alveolar ventilation.Method used mostly nowadays : arterial puncture which is accurate but is invasive 、painful、 non-dynamic and there is risk of infection and tissue、nerve damage. Noninvasive measurement methods (Most commonly used)： end-tidal CO2（ ETCO2）、 transcutaneous CO2(TcCO2). They all can monitor the PaCO2 dynamically、 noninvasively, but is existence of controversy of the accuracy. So the investigators want to compare the accuracy of these two noninvasive methods for assessment of PaCO2.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-07-29
• Study First Submitted QC: 2019-08-08
• Study First Posted: 2019-08-09
• Study Start: 2019-08-10
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-21
• Last Update Posted: 2019-10-23
• Primary Completion: 2020-06-01
• Study Completion: 2020-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• COPD patients

Exclusion Criteria

• hemodynamics is unstable;
• any other lung disease despite COPD；
• other diseases influencing experiments: Cognitive impairment disease、 mouth and nose trauma.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
concordance between the values of PetCO2 and PaCO2 measured at the same time	1 hour	concordance between the values of PetCO2 and PaCO2 measured at the same time
concordance between the values of PtcO2 and PaCO2 measured at the same time	1 hour	concordance between the values of PtcO2 and PaCO2 measured at the same time

Trial Locations

Locations (1)

The First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China