The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients With NIV Treatment

• Conditions: COPD
• Interventions: Other: no intervention

• Registration Number: NCT04258982
• Lead Sponsor: Zhenfeng He

Brief Summary

The chronic obstructive pulmonary disease (COPD) patients with type II respiratory failure always needs PaCO2 test to monitor the changes of disease. Method used mostly nowadays to detect PaCO2 is arterial puncture which is accurate but is invasive, painful and non-dynamic. Noninvasive measurement methods includes end-tidal CO2 (PetCO2), transcutaneous CO2 (PtcCO2) which can monitor the PaCO2 dynamically and noninvasively, but their accuracy is in controversy. Common PetCO2 is especially inaccurate in COPD patients while our team find that the accuracy can be improved by prolong expiration method (PetCO2 (P)).So the investigators want to compare the accuracy of PtcCO2 and PetCO2(P) in AECOPD patients during noninvasive ventilation(NIV).

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-08
• Study First Submitted: 2020-02-02
• Study First Submitted QC: 2020-02-05
• Study First Posted: 2020-02-06
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-21
• Last Update Posted: 2021-02-23
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• AECOPD patients with type II respiratory failure who need NIV treatment

Exclusion Criteria

• hemodynamics is unstable;
• any other lung disease despite COPD;
• other diseases influencing experiments: Cognitive impairment disease mouth and nose trauma.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AECOPD group	no intervention	The study incruit AECOPD patients with type II respiratory failure who need the NIV treatment.

Primary Outcome Measures

Name	Time	Method
partial arterial pressure of end-tidal CO2 measured by prolong expiration method [PetCO2(P)]	2 hours	PetCO2(P) will be measured before and after NIV treatment.
partial arterial pressure of transcutaneous CO2 (PtcCO2)	2 hours	PtcCO2 will be measured before and after NIV treatment.
partial arterial pressure of carbon dioxide (PaCO2)	2 hours	PaCO2 will be measured before and after NIV treatment.

Trial Locations

Locations (1)

The First Affiliated Hospital of Guangzhou Medical University.; 🇨🇳 Guangzhou, Guangdong, China