A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
- Registration Number
- NCT06468228
- Lead Sponsor
- AbbVie
- Brief Summary
Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts, under armpits, inner thighs, groin and buttocks. This study will compare lutikizumab versus placebo for the treatment of adult and adolescent participants with moderate to severe HS .
Lutikizumab is an investigational drug being developed for the treatment of HS. During Period 1 of the study, participants will placed in 1 of 2 groups called treatment arms. There is a 1 in 2 chance that participants will be assigned to placebo. Around 1280 adult and adolescent participants with moderate to severe HS will be enrolled in the study at approximately 275 sites world wide. During Period 2, participants that were part of the lutikizumab treatment arm in Period 1 will be re-randomized to 1 of 2 lutikizumab treatment arms. Participants that were part of the Placebo arm in Period 1 will start Period 2 with an initiation of lutikizumab followed by a re-randomization to 1 of 2 lutikizumab treatment arms.
In Period 1, participants will receive subcutaneous injections of lutikizumab or placebo every week for 16 weeks. In Period 2, participants that were randomized to lutikizumab in Period 1 will receive subcutaneous injections of lutikizumab every week or every other week for 36-weeks. Participants that were randomized to the placebo arm in Period 1 will receive subcutaneous injections of lutikizumab every week for 16 weeks, then either every week or every other week for 20 weeks
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires and diaries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1280
- Diagnosis of moderate to severe HS for at least 6 months prior to Baseline as determined by the investigator (i.e., through medical history and interview of participant).
- Total abscess and inflammatory nodule (AN) count of ≥ 5 at Baseline
- Hidradenitis suppurativa (HS) lesions present in at least two distinct anatomic areas at Baseline.
- At least 1 anatomic area of HS involvement characterized as Hurley Stage II or higher at Baseline.
- Any evidence of Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
- Confirmed positive anti-HIV antibody (HIV Ab) test.
- Evidence of active tuberculosis or meets tuberculosis exclusionary parameter
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Period 1 Lutikizumab Participants will be randomized to either Lutikizumab Dose B at baseline followed by Lutikizumab Dose A, or a matching placebo dose equivalent for both, every week through Week 16 . Period 2: Placebo to Lutikizumab Group Every Other Week Lutikizumab The participants that were assigned Placebo in Period 1 and initiated lutikizumab in Period 2 will then be re-randomized to lutikizumab Dose A every other week through Week 52 Period 1 Placebo Participants will be randomized to either Lutikizumab Dose B at baseline followed by Lutikizumab Dose A, or a matching placebo dose equivalent for both, every week through Week 16 . Period 2: Lutikizumab Every Week Lutikizumab Participants randomized to lutikizumab in Period 1 who complete Week 16 of the study will be re-randomized to lutikizumab Dose A through Week 52 Period 2: Placebo to Lutikizumab Group Every Other Week Placebo The participants that were assigned Placebo in Period 1 and initiated lutikizumab in Period 2 will then be re-randomized to lutikizumab Dose A every other week through Week 52 Period 2: Lutikizumab Every Other Week Placebo Participants randomized to lutikizumab in Period 1 who complete Week 16 of the study will be re-randomized to lutikizumab Dose A every other week though week 52 Period 2: Placebo to Lutikizumab Group Lutikizumab Participants randomized to Placebo in Period 1 who complete Week 16 of the study will initiate lutikizumab with Dose B followed by Dose A every week. Period 2: Lutikizumab Every Other Week Lutikizumab Participants randomized to lutikizumab in Period 1 who complete Week 16 of the study will be re-randomized to lutikizumab Dose A every other week though week 52 Period 2: Placebo to Lutikizumab Group Every Week Lutikizumab Participants that were assigned Placebo in Period 1 and initiated lutikizumab in Period 2 will then be re-randomized to lutikizumab Dose A every week through Week 52
- Primary Outcome Measures
Name Time Method Number of Participants with Adverse Events (AEs) Up to Approximately Week 62 An AE is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.
Percentage of Participants Achieving Hidradenitis Suppurative Clinical Response (HiSCR) 75 At Week 16 HiSCR 75 is defined as at least a 75% reduction from baseline in the total abscess and inflammatory nodule (AN) count, with no increase in abscess count and no increase in draining fistula count relative to baseline.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Numeric Rating Scale (NRS) 30 among Participants with Baseline NRS >=3 At Week 8 NRS 30 is defined as at least a 30% reduction and at least 1-unit reduction from Baseline in worst skin pain (maximal daily pain), as assessed by the Patient's Global Assessment (PGA) of Skin Pain.
Change from Baseline in Dermatology Life Quality Index (DLQI) At Week 16 DLQI (Dermatology Life Quality Index) assesses symptoms and impacts of dermatologic diseases on quality of life. DLQI scores range from 0 (no effect) to 30 (very large effect), with a higher score indicating a more impaired quality of life.
Change from Baseline in Hidradenitis Suppurativa Impact Assessment (HSIA) At Week 16 The HSIA is an 18-item PRO questionnaire developed to assess the impact of HS on the daily lives of subjects in the 7 days prior to the assessment. Items 1 - 16 of the HSIA are scored on a 0 to 10 NRS, where 0 represents no impact and 10 represents extreme impact.
Change from Baseline in Hidradenitis Suppurativa Symptom Assessment (HSSA) Worst Drainage Score At Week 16 The HSSA (24-hour recall) is a 9-item PRO questionnaire developed to assess the primary symptoms of Hidradenitis Suppurativa (HS) in the 7 consecutive days prior to assessments. Each item of the HSSA is scored on an 11-point (0 to 10) NRS, where 0 represents no symptoms and 10 represents extreme symptom experience.
Change from Baseline in Draining Fistula Count At Week 16 Percentage of Participants Achieving HiSCR 90 At Week 16 HiSCR 90 is defined as at least a 90% reduction from baseline in the total abscess and inflammatory nodule (AN) count, with no increase in abscess count and no increase in draining fistula count relative to baseline.
Change from Baseline in the Patient's Global Assessment of HS-related Skin Pain (NRS) At Week 8 Change from Baseline in HSSA At Week 16 The HSSA (24-hour recall) is a 9-item PRO questionnaire developed to assess the primary symptoms of Hidradenitis Suppurativa (HS) in the 7 consecutive days prior to assessments. Each item of the HSSA is scored on an 11-point (0 to 10) NRS, where 0 represents no symptoms and 10 represents extreme symptom experience.
Change from Baseline in the Patient's Global Assessment of HS-related Odor (smell), based on the HSSA Question 8 At Week 16 The HSSA (24-hour recall) is a 9-item PRO questionnaire developed to assess the primary symptoms of HS in the 7 consecutive days prior to assessments. Each item of the HSSA is scored on an 11-point (0 to 10) NRS, where 0 represents no symptoms and 10 represents extreme symptom experience.
Percentage of Participants with an Occurrence of HS Flare in Period 1 Baseline to Week 16 HS Flare is defined as at least one occurrence of a ≥ 25% increase in AN count with a minimum absolute increase of 2 relative to Baseline.
Trial Locations
- Locations (214)
Cahaba Dermatology & Skin Health Center /ID# 263795
🇺🇸Birmingham, Alabama, United States
Medical Dermatology Specialists /ID# 263394
🇺🇸Phoenix, Arizona, United States
Dermatology Trial Associates /ID# 264587
🇺🇸Bryant, Arkansas, United States
Arkansas Research Trials /ID# 263901
🇺🇸North Little Rock, Arkansas, United States
Joseph Raoof Md,Inc /Id# 263756
🇺🇸Encino, California, United States
Dermatology Research Associates - Los Angeles /ID# 263765
🇺🇸Los Angeles, California, United States
Stanford University School of Medicine - Redwood City /ID# 263711
🇺🇸Redwood City, California, United States
Integrative Skin Science and Research /ID# 264600
🇺🇸Sacramento, California, United States
Clinical Trials Research Institute /ID# 263743
🇺🇸Thousand Oaks, California, United States
Clearlyderm Dermatology - West Boca /ID# 265023
🇺🇸Boca Raton, Florida, United States
Apex Clinical Trials /ID# 263815
🇺🇸Brandon, Florida, United States
TrueBlue Clinical Research /ID# 265041
🇺🇸Brandon, Florida, United States
Skin Care Research - Hollywood /ID# 263805
🇺🇸Hollywood, Florida, United States
GSI Clinical Research, LLC /ID# 263827
🇺🇸Margate, Florida, United States
Sullivan Dermatology /ID# 263511
🇺🇸Miami, Florida, United States
Renstar Medical Research - Ocala - Northeast 1st Avenue /ID# 263842
🇺🇸Ocala, Florida, United States
Skin Care Research - Tampa /ID# 263819
🇺🇸Tampa, Florida, United States
Advanced Clinical Research Institute /ID# 263808
🇺🇸Tampa, Florida, United States
Alliance Clinical Research of Tampa /ID# 264594
🇺🇸Tampa, Florida, United States
Centricity Research Columbus Dermatology /ID# 266530
🇺🇸Columbus, Georgia, United States
Cleaver Medical Group Dermatology /ID# 263845
🇺🇸Dawsonville, Georgia, United States
Treasure Valley Medical Research /ID# 263671
🇺🇸Boise, Idaho, United States
Northwestern University Feinberg School of Medicine /ID# 265007
🇺🇸Chicago, Illinois, United States
Arlington Dermatology /ID# 263410
🇺🇸Rolling Meadows, Illinois, United States
Dawes Fretzin, LLC /ID# 264601
🇺🇸Indianapolis, Indiana, United States
Dermatology Partners of Leawood /ID# 263533
🇺🇸Leawood, Kansas, United States
Equity Medical, LLC /ID# 268590
🇺🇸Bowling Green, Kentucky, United States
Dermatology Specialists Research (DS Research) - Kentucky /ID# 263343
🇺🇸Louisville, Kentucky, United States
Hamzavi Dermatology - Canton /ID# 263538
🇺🇸Canton, Michigan, United States
Michigan Center for Medical Research /ID# 263547
🇺🇸Clarkston, Michigan, United States
Dermatology and Skin Center of Lees Summit /ID# 263567
🇺🇸Lee's Summit, Missouri, United States
MediSearch Clinical Trials /ID# 263582
🇺🇸Saint Joseph, Missouri, United States
Vivida Dermatology- Flamingo /ID# 263716
🇺🇸Las Vegas, Nevada, United States
Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263713
🇺🇸Lebanon, New Hampshire, United States
ActivMed Practice and Research, LLC /ID# 263387
🇺🇸Portsmouth, New Hampshire, United States
Mount Sinai Doctors - Dermatology /ID# 264602
🇺🇸New York, New York, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 264507
🇺🇸Winston-Salem, North Carolina, United States
Dermatology of Greater Columbus /ID# 263497
🇺🇸Bexley, Ohio, United States
University Hospitals Cleveland Medical Center /ID# 263600
🇺🇸Cleveland, Ohio, United States
Ohio State Officenter Gahanna /ID# 263598
🇺🇸Gahanna, Ohio, United States
Dermatologists of Southwest Ohio - Mason /ID# 263588
🇺🇸Mason, Ohio, United States
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 263076
🇩🇪Berlin, Germany
Apex Clinical Research Center /ID# 272787
🇺🇸Mayfield Heights, Ohio, United States
Dermatology Partners /ID# 264999
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center /ID# 264590
🇺🇸Pittsburgh, Pennsylvania, United States
Clinical Research Center of the Carolinas /ID# 263407
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina /ID# 263890
🇺🇸Charleston, South Carolina, United States
ADCS - Spartanburg /ID# 267207
🇺🇸Spartanburg, South Carolina, United States
Arlington Research Center, Inc /ID# 263895
🇺🇸Arlington, Texas, United States
Bellaire Dermatology Associates /ID# 263850
🇺🇸Bellaire, Texas, United States
Studies in Dermatology LLC /ID# 263399
🇺🇸Cypress, Texas, United States
Reveal Research Institute, Dallas /ID# 267233
🇺🇸Dallas, Texas, United States
Center for Clinical Studies - Houston - Binz Street /ID# 263378
🇺🇸Houston, Texas, United States
Texas Dermatology Research Center /ID# 264488
🇺🇸Plano, Texas, United States
Texas Dermatology and Laser Specialists /ID# 263778
🇺🇸San Antonio, Texas, United States
Dermatology Associates of Tyler /ID# 265002
🇺🇸Tyler, Texas, United States
University of Utah /ID# 263818
🇺🇸Murray, Utah, United States
Virginia Clinical Research /ID# 264553
🇺🇸Norfolk, Virginia, United States
Dermatology Specialists of Spokane /ID# 264499
🇺🇸Spokane, Washington, United States
Paratus Clinical Research Woden /ID# 263125
🇦🇺Phillip, Australian Capital Territory, Australia
Momentum Clinical Research /ID# 263192
🇦🇺Darlinghurst, New South Wales, Australia
Premier Dermatology /ID# 263124
🇦🇺Kogarah, New South Wales, Australia
Veracity Clinical Research /ID# 263126
🇦🇺Woolloongabba, Queensland, Australia
Sinclair Dermatology - Melbourne /ID# 263121
🇦🇺East Melbourne, Victoria, Australia
Medizinische Universitaet Graz /ID# 263306
🇦🇹Graz, Steiermark, Austria
Medizinische Universitaet Wien /ID# 264043
🇦🇹Wien, Austria
FACET Dermatology /ID# 265267
🇨🇦Toronto, Ontario, Canada
Universite Libre de Bruxelles - Hopital Erasme /ID# 263097
🇧🇪Anderlecht, Bruxelles-Capitale, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 263096
🇧🇪Bruxelles, Bruxelles-Capitale, Belgium
Universitair Ziekenhuis Brussel /ID# 263101
🇧🇪Jette, Bruxelles-Capitale, Belgium
Grand Hopital de Charleroi - I.M.T.R /ID# 263100
🇧🇪Charleroi, Hainaut, Belgium
CHU de Liège /ID# 263095
🇧🇪Liège, Liege, Belgium
UZ Gent /ID# 263099
🇧🇪Gent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 263098
🇧🇪Leuven, Vlaams-Brabant, Belgium
Klinicki centar Banja Luka /ID# 265909
🇧🇦Banja Luka, Republika Srpska, Bosnia and Herzegovina
Acibadem City Clinic Tokuda Hospital /ID# 263300
🇧🇬Sofiya, Sofia, Bulgaria
ASMC-IPSMC-Skin and Venereal Diseases /ID# 262891
🇧🇬Sofiya, Sofia, Bulgaria
Medical Center Hera EOOD /ID# 263010
🇧🇬Sofiya, Sofia, Bulgaria
Medical Center Cordis /ID# 262894
🇧🇬Pleven, Bulgaria
Diagnostic consultative center Focus-5 /ID# 262893
🇧🇬Sofiya, Bulgaria
UMHAT Professor Stoyan Kirkovich /ID# 262892
🇧🇬Stara Zagora, Bulgaria
Beacon Dermatology Inc /ID# 264262
🇨🇦Calgary, Alberta, Canada
Rejuvenation Dermatology - Edmonton Downtown /ID# 265963
🇨🇦Edmonton, Alberta, Canada
Stratica Dermatology /ID# 265856
🇨🇦Edmonton, Alberta, Canada
Interior Dermatology Centre - Probity - PPDS /ID# 266202
🇨🇦Kelowna, British Columbia, Canada
Brunswick Dermatology Center /ID# 264260
🇨🇦Fredericton, New Brunswick, Canada
Karma Clinical Trials /ID# 265962
🇨🇦St. John's, Newfoundland and Labrador, Canada
Leader Research /ID# 266114
🇨🇦Hamilton, Ontario, Canada
DermEffects /ID# 265262
🇨🇦London, Ontario, Canada
Derm Care Clinic /ID# 265261
🇨🇦Mississauga, Ontario, Canada
SKiN Centre for Dermatology /ID# 267735
🇨🇦Peterborough, Ontario, Canada
York Dermatology Clinic & Research Centre /ID# 265265
🇨🇦Richmond Hill, Ontario, Canada
Private Practice - Dr. Kim Papp Clinical Research /ID# 265266
🇨🇦Waterloo, Ontario, Canada
Diex Recherche Québec /ID# 265263
🇨🇦Québec, Quebec, Canada
Centre de Recherche Saint-Louis /ID# 265855
🇨🇦Québec, Quebec, Canada
Private Practice - Dr. Angelique Gagne-Henley /ID# 264263
🇨🇦St-Jérôme, Quebec, Canada
SkinSense Dermatology /ID# 265964
🇨🇦Saskatoon, Saskatchewan, Canada
Specialty hospital Medico /ID# 263922
🇭🇷Rijeka, Croatia
Fakultní nemocnice Ostrava /ID# 264041
🇨🇿Ostrava, Ostrava-mesto, Czechia
Karlovarska Krajska Nemocnice - Karlovy Vary /ID# 265354
🇨🇿Karlovy Vary, Czechia
Herlev and Gentofte Hospital /ID# 265839
🇩🇰Hellerup, Hovedstaden, Denmark
Aarhus Universitetshospital - Skejby /ID# 265657
🇩🇰Aarhus, Midtjylland, Denmark
Hopital Edouard Herriot /ID# 263456
🇫🇷Lyon, Auvergne-Rhone-Alpes, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 263459
🇫🇷St-Priest-en-Jarez, Loire, France
Centre Hospitalier Universitaire de Rouen (CHU)- Hopital Charles Nicolle /ID# 263995
🇫🇷Rouen, Seine-Maritime, France
Groupe Hospitalier Paris Saint-Joseph /ID# 263996
🇫🇷Paris, France
Polyclinique Courlancy /ID# 263313
🇫🇷Reims, France
Universitaetsklinikum Freiburg /ID# 263659
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Universitaetsklinikum Tuebingen /ID# 271718
🇩🇪Tübingen, Baden-Wuerttemberg, Germany
Universitaetsklinikum Erlangen /ID# 263075
🇩🇪Erlangen, Bayern, Germany
Beldio Research GmbH /ID# 263074
🇩🇪Memmingen, Bayern, Germany
Rosenpark Research /ID# 269202
🇩🇪Darmstadt, Hessen, Germany
Fachklinik Bad Bentheim /ID# 263067
🇩🇪Bad Bentheim, Niedersachsen, Germany
Katholisches Klinikum Bochum /ID# 262976
🇩🇪Bochum, Nordrhein-Westfalen, Germany
Universitaetsklinikum Muenster /ID# 263068
🇩🇪Muenster, Nordrhein-Westfalen, Germany
Hautarztpraxis Mortazawi /ID# 271673
🇩🇪Remscheid, Nordrhein-Westfalen, Germany
Hautarztpraxis Dr. Kirschner /ID# 263656
🇩🇪Mainz, Rheinland-Pfalz, Germany
University General Hospital Attikon /ID# 263413
🇬🇷Athens, Attiki, Greece
General Hospital Andreas Syggros /ID# 263417
🇬🇷Athens, Attiki, Greece
Hospital of Skin and Venereal Diseases- Thessaloniki /ID# 263416
🇬🇷Thessaloniki, Greece
Papageorgiou General Hospital /ID# 263415
🇬🇷Thessaloniki, Greece
Debreceni Egyetem-Klinikai Kozpont /ID# 263423
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Semmelweis Egyetem /ID# 263451
🇭🇺Budapest, Hungary
Pécsi Tudományegyetem /ID# 264120
🇭🇺Pécs, Hungary
Our Lady of Lourdes Hospital - Drogheda /ID# 265893
🇮🇪Drogheda, Louth, Ireland
South Infirmary Victoria University Hospital /ID# 265872
🇮🇪Cork, Ireland
University College Dublin /ID# 265875
🇮🇪Dublin, Ireland
Mater Misericordiae University Hospital /ID# 265914
🇮🇪Dublin, Ireland
HaEmek Medical Center /ID# 267297
🇮🇱Afula, H_efa, Israel
Rambam Health Care Campus /ID# 262994
🇮🇱Haifa, H_efa, Israel
Rabin Medical Center /ID# 262992
🇮🇱Petah Tikva, HaMerkaz, Israel
Galilee Medical Center /ID# 262995
🇮🇱Naharia, HaTsafon, Israel
The Chaim Sheba Medical Center /ID# 262993
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 266581
🇮🇱Tel Aviv, Tel-Aviv, Israel
Hadassah Medical Center-Hebrew University /ID# 262884
🇮🇱Jerusalem, Israel
AZIENDA USL TOSCANA CENTRO - Ospedale Piero Palagi /ID# 263454
🇮🇹Florence, Firenze, Italy
Azienda Ospedaliera Universitaria Federico II /ID# 263539
🇮🇹Naples, Napoli, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 263473
🇮🇹Rome, Roma, Italy
AOU Policlinico G. Rodolico - San Marco /ID# 263469
🇮🇹Catania, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 263471
🇮🇹Milano, Italy
Nagoya City University Hospital /ID# 263874
🇯🇵Nagoya, Aichi, Japan
Fujita Health University Hospital /ID# 265440
🇯🇵Toyoake, Aichi, Japan
Takagi Dermatological Clinic /ID# 264810
🇯🇵Obihiro-Shi, Hokkaido, Japan
Iwate Medical University Uchimaru Medical Center /ID# 273799
🇯🇵Morioka, Iwate, Japan
University Hospital Kyoto Prefectural University of Medicine /ID# 264291
🇯🇵Kyoto-shi, Kyoto, Japan
University of the Ryukyus Hospital /ID# 264605
🇯🇵Ginowan-shi, Okinawa, Japan
Osaka Metropolitan University Hospital /ID# 265682
🇯🇵Osaka-shi, Osaka, Japan
Kindai University Hospital /ID# 264322
🇯🇵Osakasayama-shi, Osaka, Japan
Dokkyo Medical University Saitama Medical Center /ID# 265400
🇯🇵Koshigaya, Saitama, Japan
Fukuoka University Hospital /ID# 263991
🇯🇵Fukuoka, Japan
Nihon University Itabashi Hospital /ID# 264661
🇯🇵Tokyo, Japan
SoonChunHyang University Hospital Cheonan /ID# 271320
🇰🇷Cheonan-si, Chungcheongnamdo, Korea, Republic of
Korea University Ansan Hospital /ID# 264227
🇰🇷Ansan-si, Gyeonggido, Korea, Republic of
CHA Bundang Medical Center /ID# 264225
🇰🇷Seongnam, Gyeonggido, Korea, Republic of
Yonsei University Health System Severance Hospital /ID# 271353
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
SoonChunHyang University Seoul Hospital /ID# 264224
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center /ID# 264228
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital /ID# 264226
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Erasmus Medisch Centrum /ID# 263377
🇳🇱Rotterdam, Zuid-Holland, Netherlands
Clinical Trials New Zealand /ID# 265432
🇳🇿Hamilton, Waikato, New Zealand
Greenlane Clinical Centre /ID# 263191
🇳🇿Auckland, New Zealand
Stavanger Universitetssykehus /ID# 265997
🇳🇴Stavanger, Rogaland, Norway
Universitetssykehuset I Nord-Norge /ID# 265992
🇳🇴Tromsø, Troms, Norway
Oslo University Hospital - Rikshospitalet /ID# 265996
🇳🇴Oslo, Norway
Oftalmika sp. z o.o. /ID# 263087
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
DERMED Centrum Medyczne Sp. z o.o /ID# 263147
🇵🇱Lodz, Lodzkie, Poland
Santa Sp. z o..o. Santa Familia PTG Lodz /ID# 263181
🇵🇱Lodz, Lodzkie, Poland
Centrum Nowoczesnych Terapii 'Dobry Lekarz' sp.z.o.o. /ID# 263146
🇵🇱Krakow, Malopolskie, Poland
Klinika Ambroziak Dermatologia /ID# 263173
🇵🇱Warszawa, Mazowieckie, Poland
Unidade Local de Saude do Alto Ave, EPE /ID# 265158
🇵🇹Guimaraes, Braga, Portugal
CUF Descobertas Hospital /ID# 263188
🇵🇹Lisbon, Lisboa, Portugal
Unidade Local de Saude de Sao Jose, EPE /ID# 265155
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Santo Antonio, E.P.E. /ID# 265479
🇵🇹Porto, Portugal
Private Practice - Dr. Alma Cruz /ID# 263204
🇵🇷Carolina, Puerto Rico
Clinical Research Puerto Rico /ID# 263450
🇵🇷San Juan, Puerto Rico
Private Practice - Dr. Orasan Remus /ID# 263305
🇷🇴Cluj Napoca, Cluj, Romania
Spitalul Clinic Colentina /ID# 263303
🇷🇴Bucharest, Romania
Centrul Medical Euromed /ID# 263304
🇷🇴Bucharest, Romania
Military Medical Academy /ID# 263257
🇷🇸Belgrade, Beograd, Serbia
University Clinical Center Serbia /ID# 263256
🇷🇸Belgrade, Beograd, Serbia
University Clinical Center Kragujevac /ID# 264211
🇷🇸Kragujevac, Sumadijski Okrug, Serbia
University Clinical Center Vojvodina /ID# 263260
🇷🇸Novi Sad, Serbia
National University Hospital /ID# 264673
🇸🇬Singapore, Singapore
National Skin Centre /ID# 264680
🇸🇬Singapore, Singapore
Univerzitna nemocnica L. Pasteura Kosice /ID# 263907
🇸🇰Košice, Kosicky Kraj, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 265944
🇸🇰Nové Zámky, Nitriansky Kraj, Slovakia
Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 263921
🇸🇰Bratislava, Slovakia
Fakultna nemocnica Trnava /ID# 263905
🇸🇰Trnava, Slovakia
University Medical Centre Ljubljana /ID# 265720
🇸🇮Ljubljana, Slovenia
University Medical Centre Maribor /ID# 265827
🇸🇮Maribor, Slovenia
Global Clinical Trials /ID# 262839
🇿🇦Pretoria, Gauteng, South Africa
Life Chatsmed Garden Hospital /ID# 270237
🇿🇦Chatsworth, Kwazulu-Natal, South Africa
Ahmed Al-Kadi Private Hospital /ID# 262837
🇿🇦Durban, Kwazulu-Natal, South Africa
Dr Ahmed Ismail Manjra /ID# 262838
🇿🇦Westville, Kwazulu-Natal, South Africa
Hospital Universitari Parc Tauli /ID# 262942
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario Marqués de Valdecilla /ID# 263039
🇪🇸Santander, Cantabria, Spain
Hospital Universitario Virgen de la Victoria /ID# 262941
🇪🇸Málaga, Malaga, Spain
Hospital de Manises /ID# 262938
🇪🇸Manises, Valencia, Spain
Hospital General Universitario Gregorio Marañón /ID# 262940
🇪🇸Madrid, Spain
Consorci Hospital General Universitario de Valencia /ID# 262944
🇪🇸Valencia, Spain
Karolinska University Hospital Solna /ID# 264530
🇸🇪Solna, Stockholms Lan, Sweden
Universitetssjukhuset Örebro /ID# 265064
🇸🇪Örebro, Sweden
Dermatology & Skin Care Clinic /ID# 264030
🇨🇭Buochs, Nidwalden, Switzerland
Kantonsspital St.Gallen /ID# 264238
🇨🇭St. Gallen, Sankt Gallen, Switzerland
University Hospital Zurich /ID# 266142
🇨🇭Zurich, Zuerich, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 264619
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
National Taiwan University Hospital /ID# 264618
🇨🇳Taipei City, Taipei, Taiwan
Taichung Veterans General Hospital /ID# 270741
🇨🇳Taichung, Taiwan
Mackay Memorial Hospital /ID# 263661
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hospital /ID# 265879
🇨🇳Taipei City, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 264620
🇨🇳Taoyuan City, Taiwan
Queen Margaret Hospital /ID# 264198
🇬🇧Dunfermline, Fife, United Kingdom
Barts Health NHS Trust /ID# 264121
🇬🇧London, Greater London, United Kingdom
Harrogate District Hospital /ID# 265632
🇬🇧Harrogate, North Yorkshire, United Kingdom