A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
- Registration Number
- NCT05889182
- Lead Sponsor
- AbbVie
- Brief Summary
Hidradenitis suppurativa (HS) is an inflammatory skin disease that causes painful lesions in the axilla (underarm), inguinal (groin) and anogenital (anal/genital) regions. This study will assess how safe and effective upadacitinib is in treating adult and adolescent participants with moderate to severe HS who have failed to respond to or are intolerant of anti-tumor necrosis factor (TNF) therapy. Adverse events and change in disease activity will be assessed.
Upadacitinib is an approved drug for ulcerative colitis, atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of HS. This study is "double-blinded", meaning that neither the trial participants nor the study doctors will know who will be given upadacitinib and who will be given placebo. This study is comprised of 3 periods. In Period 1, participants are randomized into 2 groups called treatment arms where each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to placebo. In Period 2, participants are placed into 6 different groups depending on their placement and results in Period 1. Period 3 is the long-term extension period where participants will continue treatment from Period 2. Approximately 1328 adult and adolescent participants diagnosed with HS will be enrolled in approximately 275 sites worldwide.
Participants will receive oral tablets of upadacitinib or placebo once daily for 36 weeks in Period 1 and Period 2. Eligible participants from Period 1 and Period 2 will enter Period 3 and receive oral tablets of upadacitinib or placebo once daily for 68 weeks. Participants will be followed up for approximately 30 days.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular outpatient visits during the study. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1328
- Diagnosis of HS for at least 6 months prior to Baseline, as determined by the investigator (i.e., through medical history and interview of subject).
- Documented history of previous use of ≥ 1 TNF inhibitor for HS for at least 12 weeks and/or 1 approved non-anti-TNF biologic therapy for HS for at least 16 weeks characterized by inadequate response or for any duration characterized by intolerance as determined by the investigator.
- Participant must have a total AN count of ≥ 5 at Baseline.
- HS lesions must be present in at least 2 distinct anatomic areas at Baseline.
- At least 1 anatomic area of HS involvement characterized as Hurley Stage II or higher at Baseline.
- Draining fistula count of ≤ 20 at Baseline.
- History of active skin disease other than HS that could interfere with the assessment of HS, including skin infections (bacterial, fungal, or viral) requiring systemic treatment within 4 weeks of the Baseline visit.
- Treatment with any investigational drug of chemical or biologic nature within a minimum of 30 days or 5 half-lives (whichever is longer) prior to the first dose of study drug or be currently enrolled in another interventional clinical study. Investigational drugs are also prohibited during the study.
- Previous treatment with any cell-depleting therapies including but not limited to anti-CD20 (e.g., rituximab) within 12 months prior to Baseline or until B cell count returns to normal level or pre-treatment level.
- Use of prescription topical therapies (including topical antibiotics) that can also be used to treat HS within 14 days prior to the Baseline visit.
- Received any systemic (including oral) antibiotic treatment for HS or any other chronic inflammatory disorder within 14 days prior to the Baseline visit.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Period 2: Group 2 - Placebo Placebo Participants who were randomized to placebo in Period 1 who achieve HiSCR 50 (clinical responder, CR) at Week 16 will continue to receive placebo once daily for 20 weeks. Period 2: Group 3 - Upadacitinib Dose A Upadacitinib Participants who were randomized to upadacitinib Dose A in Period 1 who did not achieve HiSCR 50 (CNR) at Week 16 will continue to receive upadacitinib Dose A once daily for 20 weeks. Period 2: Group 6 - Placebo Placebo Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive placebo once daily for 20 weeks. Period 1: Placebo Placebo Participants will receive Placebo once daily for 16 weeks. Period 2: Group 1 - Upadacitinib Dose A Upadacitinib Participants who were randomized to placebo in Period 1 who did not achieve HiSCR 50 (clinical non-responder, CNR) at Week 16 will receive Upadacitinib Dose A once daily for 20 weeks. Period 2: Group 4 - Upadacitinib Dose A Upadacitinib Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive upadacitinib Dose A once daily for 20 weeks. Period 3: Long-Term Extension Placebo Eligible participants will continue to receive upadacitinib or placebo for 68 weeks. Participants will be followed-up for approximately 30 days. Period 3: Long-Term Extension Upadacitinib Eligible participants will continue to receive upadacitinib or placebo for 68 weeks. Participants will be followed-up for approximately 30 days. Period 2: Group 5 - Upadacitinib Dose B Upadacitinib Participants who were randomized to upadacitinib Dose A in Period 1 who achieve HiSCR 50 (CR) at Week 16 will receive upadacitinib Dose B once daily for 20 weeks. Period 1: Upadacitinib Dose A Upadacitinib Participants will receive Upadicitinib Dose A once daily for 16 weeks.
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Hidradenitis Suppurative Clinical Response (HiSCR) 50 Baseline to Week 16 HiSCR 50 is defined as at least a 50% reduction in the total abscess and inflammatory nodule (AN) count with no increase in abscess count and no increase in draining fistula count relative to Baseline.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Numeric Rating Scale 30 (NRS30) at Week 4 Among Participants with NRS ≥ 3 at Baseline Baseline to Week 4 Achievement will be considered at least a 30% reduction and at least 2 units reduction from Baseline in the Participant's Global Assessment (PGA) of HS-related skin pain NRS based on worst skin pain in a 24-hour recall period (maximal daily pain). The PGA Skin Pain is an 11-point numerical rating scale with ratings for the item ranging from 0 (no skin pain) to 10 (skin pain as bad as you can imagine).
Occurrence of Hidradenitis Suppurativa (HS) Flare During Period 1 Week 16 Defined as at least one occurrence of a ≥ 25% increase in AN count, with a minimum absolute increase of 2 relative to Baseline.
Change from Baseline in Hidradenitis Suppurativa Symptom Assessment (HSSA) Baseline to Week 16 The HSSA (24-hour recall) is a 9-item PRO questionnaire developed to assess the primary symptoms of HS in the 7 consecutive days prior to assessments. Each item of the HSSA is scored on an 11-point (0 to 10) NRS, where 0 represents no symptoms and 10 represents extreme symptom experience.
Change from Baseline in Hidradenitis Suppurativa Impact Assessment (HSIA) Baseline to Week 16 The HSIA is an 18-item PRO questionnaire developed to assess the impact of HS on the daily lives of subjects in the 7 days prior to the assessment. Items 1 - 16 of the HSIA are scored on a 0 to 10 NRS, where 0 represents no impact and 10 represents extreme impact.
Percentage of Participants Achieving Hidradenitis Suppurative Clinical Response (HiSCR) 75 Baseline to Week 16 HiSCR 75 is defined as at least a 75% reduction in the total abscess and inflammatory nodule (AN) count with no increase in abscess count and no increase in draining fistula count relative to Baseline.
Change from Baseline in Dermatology Life Quality Index (DLQI) for Adult Participants and Adolescent Participants Age ≥16 Years Old Baseline to Week 16 The DLQI and the CDLQI are both 10-item questionnaires used to assess the impact of hidradenitis suppurativa (HS) disease symptoms and treatment on quality of life that consists of 10 questions scored on a 4-point scale where 0 = not at all/not relevant; 1 = a little; 2 = a lot; and 3 = very much.
Change from Baseline in Hidradenitis Suppurativa (HS)-Related Odor, Based on Hidradenitis Suppurativa Symptom Assessment (HSSA) Question 8 Baseline to Week 16 The HSSA (24-hour recall) is a 9-item PRO questionnaire developed to assess the primary symptoms of HS in the 7 consecutive days prior to assessments. Each item of the HSSA is scored on an 11-point (0 to 10) NRS, where 0 represents no symptoms and 10 represents extreme symptom experience.
Change from Baseline in the Patient's Global Assessment of Hidradenitis Suppurativa (HS)-Related Skin Pain NRS At Week 8 The PGA Skin Pain is an 11-point numerical rating scale with ratings for the item ranging from 0 (no skin pain) to 10 (skin pain as bad as you can imagine) that is used to assess the worst pain due to HS. Patients are asked to respond to the item based on a recall period of "the last 24 hours
Trial Locations
- Locations (246)
Cahaba Dermatology & Skin Health Center /ID# 254876
🇺🇸Birmingham, Alabama, United States
Medical Dermatology Specialists /ID# 254226
🇺🇸Phoenix, Arizona, United States
Mayo Clinic - Scottsdale /ID# 254388
🇺🇸Scottsdale, Arizona, United States
Banner University Medicine Dermatology /ID# 255853
🇺🇸Tucson, Arizona, United States
Clinical Trials Institute - Northwest Arkansas /ID# 254924
🇺🇸Fayetteville, Arkansas, United States
Burke Pharmaceutical Research /ID# 254238
🇺🇸Hot Springs, Arkansas, United States
Arkansas Research Trials /ID# 254233
🇺🇸North Little Rock, Arkansas, United States
NW Arkansas Clinical Trials Center /ID# 254311
🇺🇸Rogers, Arkansas, United States
Joseph Raoof Md,Inc /Id# 254374
🇺🇸Encino, California, United States
Dermatology Research Associates /ID# 254846
🇺🇸Los Angeles, California, United States
Integrative Skin Science and Research /ID# 254930
🇺🇸Sacramento, California, United States
University of California Davis Health /ID# 254229
🇺🇸Sacramento, California, United States
Medderm Associates /ID# 253800
🇺🇸San Diego, California, United States
Clinical Trials Research Institute /ID# 254466
🇺🇸Thousand Oaks, California, United States
UConn Health Main /ID# 254507
🇺🇸Farmington, Connecticut, United States
Yale University School of Medicine /ID# 254586
🇺🇸New Haven, Connecticut, United States
Skin Care Research Boca Raton /ID# 253814
🇺🇸Boca Raton, Florida, United States
Apex Clinical Trials /ID# 255756
🇺🇸Brandon, Florida, United States
Florida Academic Dermatology Center /ID# 254011
🇺🇸Coral Gables, Florida, United States
Skin Care Research - Hollywood /ID# 254508
🇺🇸Hollywood, Florida, United States
Life Clinical Trials /ID# 258613
🇺🇸Margate, Florida, United States
Skin Care Research - Tampa /ID# 256440
🇺🇸Tampa, Florida, United States
Advanced Clinical Research Institute /ID# 253746
🇺🇸Tampa, Florida, United States
Avita Clinical Research /ID# 254471
🇺🇸Tampa, Florida, United States
Centricity Research /ID# 255470
🇺🇸Columbus, Georgia, United States
Treasure Valley Medical Research /ID# 255208
🇺🇸Boise, Idaho, United States
Northwestern University Feinberg School of Medicine /ID# 254503
🇺🇸Chicago, Illinois, United States
DeNova Research /ID# 254372
🇺🇸Chicago, Illinois, United States
NorthShore University HealthSystem - Skokie /ID# 254389
🇺🇸Skokie, Illinois, United States
Dawes Fretzin, LLC /ID# 254390
🇺🇸Indianapolis, Indiana, United States
Options Research Group /ID# 254537
🇺🇸West Lafayette, Indiana, United States
U.S. Dermatology Partners Leawood /ID# 255838
🇺🇸Leawood, Kansas, United States
Massachusetts General Hospital /ID# 261093
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center /ID# 253811
🇺🇸Boston, Massachusetts, United States
Beacon Clinical Research, LLC /ID# 254419
🇺🇸Quincy, Massachusetts, United States
UMass Memorial Medical Center /ID# 258839
🇺🇸Worcester, Massachusetts, United States
Michigan Dermatology Institute /ID# 254468
🇺🇸Waterford, Michigan, United States
Dermatology and Skin Center of Lees Summit /ID# 257546
🇺🇸Lee's Summit, Missouri, United States
MediSearch Clinical Trials /ID# 254392
🇺🇸Saint Joseph, Missouri, United States
SSM Health Saint Louis University Hospital /ID# 256437
🇺🇸Saint Louis, Missouri, United States
Washington University School of Medicine - St. Louis /ID# 254506
🇺🇸Saint Louis, Missouri, United States
Vivida Dermatology- Flamingo /ID# 254227
🇺🇸Las Vegas, Nevada, United States
Skin Cancer and Dermatology Institute - Reno /ID# 254410
🇺🇸Reno, Nevada, United States
NorthWell Health - Dermatology /ID# 254704
🇺🇸New Hyde Park, New York, United States
Schweiger Dermatology, P.C. /ID# 254232
🇺🇸New York, New York, United States
Onsite Clinical Solutions /ID# 254854
🇺🇸Charlotte, North Carolina, United States
Duke University (School of Medicine) /ID# 256898
🇺🇸Durham, North Carolina, United States
ClinOhio Research Services /ID# 254851
🇺🇸Columbus, Ohio, United States
Dermatologists of Southwest Ohio, Inc /ID# 254297
🇺🇸Mason, Ohio, United States
Lynn Institute of Oklahoma City /ID# 253791
🇺🇸Oklahoma City, Oklahoma, United States
Oregon Health and Science University /ID# 254929
🇺🇸Portland, Oregon, United States
Penn State Milton S. Hershey Medical Center /ID# 254925
🇺🇸Hershey, Pennsylvania, United States
Paddington Testing Co., Inc. /ID# 254394
🇺🇸Philadelphia, Pennsylvania, United States
Clinical Research of Philadelphia, LLC /ID# 255308
🇺🇸Philadelphia, Pennsylvania, United States
Dermatology Associates of Knoxville /ID# 261082
🇺🇸Knoxville, Tennessee, United States
Arlington Research Center, Inc /ID# 253805
🇺🇸Arlington, Texas, United States
Bellaire Dermatology Associates /ID# 253797
🇺🇸Bellaire, Texas, United States
Dermatology Treatment and Research Center /ID# 253795
🇺🇸Dallas, Texas, United States
Modern Research Associates, PLLC /ID# 253810
🇺🇸Dallas, Texas, United States
HRMD Research Dallas /ID# 255256
🇺🇸Dallas, Texas, United States
Dallas Fort Worth Clinical Research Associates (DFWCRA) /ID# 256438
🇺🇸Grapevine, Texas, United States
Suzanne Bruce and Associates-Houston /ID# 254228
🇺🇸Houston, Texas, United States
Texas Dermatology Research Center, LLC /ID# 254928
🇺🇸Plano, Texas, United States
Center for Clinical Studies Webster TX /ID# 254242
🇺🇸Webster, Texas, United States
University of Utah /ID# 254452
🇺🇸Murray, Utah, United States
University of Virginia - Dermatology /ID# 254535
🇺🇸Charlottesville, Virginia, United States
The Education & Research Foundation, Inc. /ID# 254852
🇺🇸Lynchburg, Virginia, United States
Virginia Clinical Research /ID# 254538
🇺🇸Norfolk, Virginia, United States
North Sound Dermatology /ID# 254554
🇺🇸Mill Creek, Washington, United States
Premier Clinical Research /ID# 254847
🇺🇸Spokane, Washington, United States
Buenos Aires Skin /ID# 255299
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Instituto de Neumonologia y Dermatologia /ID# 254903
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Psoriahue Med Interdisciplinar /ID# 257202
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Consultorios Reumatologicos Pampa /ID# 255555
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Centro de Investigacion y Prevencion Cardiovascular (CIPREC) /ID# 255474
🇦🇷Buenos Aires, Argentina
Hospital Italiano /ID# 254905
🇦🇷Caba, Argentina
Paratus Clinical Research Woden /ID# 254670
🇦🇺Phillip, Australian Capital Territory, Australia
Momentum Clinical Research /ID# 254411
🇦🇺Darlinghurst, New South Wales, Australia
Skin Health Institute Inc /ID# 254416
🇦🇺Carlton, Victoria, Australia
Sinclair Dermatology - Melbourne /ID# 254412
🇦🇺East Melbourne, Victoria, Australia
The Alfred Hospital /ID# 254414
🇦🇺Melbourne, Victoria, Australia
Ordensklinikum Linz GmbH Elisabethinen /ID# 253458
🇦🇹Linz, Oberoesterreich, Austria
Medizinische Universitaet Graz /ID# 253448
🇦🇹Graz, Steiermark, Austria
Medizinische Universitaet Wien /ID# 254096
🇦🇹Vienna, Wien, Austria
Universite Libre de Bruxelles - Hopital Erasme /ID# 254082
🇧🇪Anderlecht, Bruxelles-Capitale, Belgium
Universitair Ziekenhuis Brussel /ID# 254223
🇧🇪Jette, Bruxelles-Capitale, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 254087
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Grand Hôpital De Charleroi - Notre Dame /ID# 254091
🇧🇪Charleroi, Hainaut, Belgium
CHU de Liège /ID# 254085
🇧🇪Liège, Liege, Belgium
UZ Gent /ID# 254090
🇧🇪Gent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 254089
🇧🇪Leuven, Vlaams-Brabant, Belgium
Instituto de Pesquisa e Ensino CLIGEDIMUNO - IPEC /ID# 254369
🇧🇷Macaé, Rio De Janeiro, Brazil
Hospital Moinhos de Vento /ID# 254366
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 254367
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Centro de Desenvolvimento em Estudos Clinicos Brasil - CDEC /ID# 254368
🇧🇷São Paulo, Sao Paulo, Brazil
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 254370
🇧🇷Sao Paulo, Brazil
Acibadem City Clinic Tokuda University Hospital EAD /ID# 253331
🇧🇬Sofia, Bulgaria
Ambulatory for Specialized Medical Care for skin and venereal diseases /ID# 253329
🇧🇬Sofia, Bulgaria
Diagnostic consultative center Focus-5 /ID# 253327
🇧🇬Sofiya, Bulgaria
UMHAT Professor Stoyan Kirkovich /ID# 253328
🇧🇬Stara Zagora, Bulgaria
Dermatology Research Institute - Blackfoot Trail /ID# 261413
🇨🇦Calgary, Alberta, Canada
Beacon Dermatology Inc /ID# 254564
🇨🇦Calgary, Alberta, Canada
Rejuvenation Dermatology - Edmonton Downtown /ID# 254715
🇨🇦Edmonton, Alberta, Canada
Dr. Chih-ho Hong Medical Inc. /ID# 254378
🇨🇦Surrey, British Columbia, Canada
Enverus Medical Research /ID# 254380
🇨🇦Surrey, British Columbia, Canada
Wiseman Dermatology Research /ID# 254117
🇨🇦Winnipeg, Manitoba, Canada
Karma Clinical Trials /ID# 254120
🇨🇦St. John's, Newfoundland and Labrador, Canada
LEADER Research /ID# 254379
🇨🇦Hamilton, Ontario, Canada
DermEffects /ID# 254116
🇨🇦London, Ontario, Canada
Lynde Institute for Dermatology /ID# 254713
🇨🇦Markham, Ontario, Canada
Dr. S.K. Siddha Medicine Professional Corporation /ID# 254714
🇨🇦Newmarket, Ontario, Canada
York Dermatology Clinic and Research Centre /ID# 254115
🇨🇦Richmond Hill, Ontario, Canada
Research Toronto /ID# 255273
🇨🇦Toronto, Ontario, Canada
CHU Sainte-Justine /ID# 254118
🇨🇦Montreal, Quebec, Canada
Diex Recherche Québec Inc. /ID# 254381
🇨🇦Québec, Quebec, Canada
Dre Angelique Gagne-Henley M.D. inc. /ID# 255632
🇨🇦Saint-Jerome, Quebec, Canada
SkinSense Dermatology /ID# 254119
🇨🇦Saskatoon, Saskatchewan, Canada
Fundacion Innovacion Cardiovascular /ID# 254561
🇨🇱Independencia, Region Metropolitana De Santiago, Chile
Centro Medico Skin Med SPA /ID# 254560
🇨🇱Las Condes, Region Metropolitana Santiago, Chile
Centro Internacional de Estudios Clinicos - CIEC /ID# 254559
🇨🇱Santiago, Region Metropolitana Santiago, Chile
Clinica Dermacross /ID# 254558
🇨🇱Vitacura, Region Metropolitana Santiago, Chile
Clinisalud del sur /ID# 254797
🇨🇴Medellin, Antioquia, Colombia
Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 255278
🇨🇴Barranquilla, Atlantico, Colombia
Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 254796
🇨🇴Bogotá, Cundinamarca, Colombia
DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 253587
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 253786
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinika za dječje bolesti Zagreb /ID# 253588
🇭🇷Zagreb, Grad Zagreb, Croatia
Poliklinika Solmed /ID# 254732
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 253789
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Naftalan - Specijalna bolnica za medicinsku rehabilitaciju /ID# 253586
🇭🇷Ivanic-Grad, Zagrebacka Zupanija, Croatia
Specialty hospital Medico /ID# 254731
🇭🇷Rijeka, Croatia
Karlovarska Krajska Nemocnice - Karlovy Vary /ID# 253456
🇨🇿Karlovy Vary, Czechia
Duplicate_Fakultni Nemocnice v Motole /ID# 253455
🇨🇿Prague, Czechia
Fakultni nemocnice Kralovske Vinohrady /ID# 253454
🇨🇿Praha, Czechia
Terveystalo Tampere /ID# 253968
🇫🇮Tampere, Pirkanmaa, Finland
Oulun yliopistollinen sairaala /ID# 253969
🇫🇮Oulu, Pohjois-Pohjanmaa, Finland
Chu de Nice-Hopital Larchet Ii /Id# 253504
🇫🇷Nice, Alpes-Maritimes, France
Centre Hospitalier Universitaire de Bordeaux - Groupe Hospitalier Saint-Andre /ID# 254139
🇫🇷Bordeaux, Gironde, France
CHU de Nantes, Hotel Dieu -HME /ID# 254114
🇫🇷Nantes, Pays-de-la-Loire, France
Hopital Prive d'Antony /ID# 253501
🇫🇷Antony, Ile-de-France, France
Polyclinique Courlancy /ID# 254680
🇫🇷Reims, Marne, France
HCL - Hopital Edouard Herriot /ID# 253500
🇫🇷Lyon, Rhone, France
Magdeburger Company for Medical Studies & Services GmbH /ID# 255151
🇩🇪Magdeburg, Germany
Klinikum Ruhr Univ Bochum /ID# 253690
🇩🇪Bochum, Germany
Universitaetsklinikum Regensburg /ID# 253692
🇩🇪Regensburg, Germany
Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 254510
🇩🇪Bramsche, Niedersachsen, Germany
Havelklinik /ID# 254194
🇩🇪Berlin, Germany
Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 253691
🇩🇪Mainz, Germany
Klinik am Biederstein /ID# 254195
🇩🇪Munich, Germany
401 GSNA - 401 Army General Hospital /ID# 253499
🇬🇷Athens, Attiki, Greece
University General Hospital Attikon /ID# 253495
🇬🇷Athens, Attiki, Greece
General Hospital Andreas Syggros /ID# 253498
🇬🇷Athens, Attiki, Greece
Papageorgiou General Hospital /ID# 253496
🇬🇷Thessaloniki, Greece
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 253913
🇭🇺Kaposvár, Somogy, Hungary
Szegedi Tudományegyetem /ID# 255142
🇭🇺Szeged, Hungary
Hospital of Skin and Venereal Diseases- Thessaloniki /ID# 253497
🇬🇷Thessaloniki, Greece
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 253753
🇭🇺Pecs, Baranya, Hungary
St James Hospital /ID# 253973
🇮🇪Dublin 8, Dublin, Ireland
South Infirmary Victoria University Hospital /ID# 253975
🇮🇪Cork, Ireland
Debreceni Egyetem-Klinikai Kozpont /ID# 253637
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 254377
🇭🇺Szombathely, Vas, Hungary
Csalogany Orvosi Kozpont /ID# 255063
🇭🇺Budapest, Hungary
Duplicate_Obudai Egeszsegugyi Centrum Kft. /ID# 256366
🇭🇺Budapest, Hungary
University Hospital Galway /ID# 253976
🇮🇪Galway, Ireland
DERMA-B Egeszsegugyi es Szolgaltato - Debrecen - Gyepusor Utca /ID# 253638
🇭🇺Debrecen, Hungary
University College Dublin /ID# 253971
🇮🇪Dublin, Ireland
Waterford Regional Hospital /ID# 254038
🇮🇪Waterford, Ireland
Rambam Health Care Campus /ID# 254406
🇮🇱Haifa, H_efa, Israel
ZIV Medical Center /ID# 254403
🇮🇱Safed, HaTsafon, Israel
Sheba Medical Center /ID# 254545
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 254404
🇮🇱Tel Aviv, Tel-Aviv, Israel
Rabin Medical Center /ID# 254405
🇮🇱Haifa, Israel
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale S.Anna /ID# 254496
🇮🇹Cona, Ferrara, Italy
AZIENDA USL TOSCANA CENTRO - Ospedale Piero Palagi /ID# 254495
🇮🇹Florence, Firenze, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 254498
🇮🇹Rome, Roma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 254500
🇮🇹Rome, Roma, Italy
ASST degli Spedali Civili di Brescia /ID# 254875
🇮🇹Brescia, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 254502
🇮🇹Milano, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 254874
🇮🇹Modena, Italy
Azienda Ospedaliero Universitaria Pisana /ID# 254501
🇮🇹Pisa, Italy
Fukuoka University Hospital /ID# 254729
🇯🇵Fukuoka-shi, Fukuoka, Japan
Meiwa Hospital /ID# 254728
🇯🇵Nishinomiya-shi, Hyogo, Japan
University of Tsukuba Hospital /ID# 254638
🇯🇵Tsukuba-shi, Ibaraki, Japan
University Hospital Kyoto Prefectural University of Medicine /ID# 254481
🇯🇵Kyoto-shi, Kyoto, Japan
Tohoku University Hospital /ID# 254598
🇯🇵Sendai-shi, Miyagi, Japan
University of the Ryukyus Hospital /ID# 254517
🇯🇵Nakagami-gun, Okinawa, Japan
Kindai University Hospital /ID# 254574
🇯🇵Osakasayama-shi, Osaka, Japan
Shiga University of Medical Science Hospital /ID# 254215
🇯🇵Otsu, Shiga, Japan
Nihon University Itabashi Hospital /ID# 254637
🇯🇵Itabashi-ku, Tokyo, Japan
Toranomon Hospital /ID# 253819
🇯🇵Minato-ku, Tokyo, Japan
Korea University Ansan Hospital /ID# 254128
🇰🇷Ansan-si, Gyeonggido, Korea, Republic of
CHA Bundang Medical Center /ID# 254026
🇰🇷Seongnam, Gyeonggido, Korea, Republic of
Seoul National University Hospital /ID# 254027
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
SoonChunHyang University Seoul Hospital /ID# 254025
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital /ID# 254127
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Inlita Santara CTC /ID# 253917
🇱🇹Vilnius, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 253916
🇱🇹Vilnius, Lithuania
Amphia Ziekenhuis /ID# 253567
🇳🇱Breda, Noord-Brabant, Netherlands
Universitair Medisch Centrum Groningen /ID# 253571
🇳🇱Groningen, Netherlands
Greenlane Clinical Centre /ID# 254351
🇳🇿Epsom, Auckland, New Zealand
Clinical Trials New Zealand /ID# 254352
🇳🇿Hamilton, Waikato, New Zealand
Hospital CUF Descobertas /ID# 254323
🇵🇹Lisboa, Portugal
Centro Hospitalar de Lisboa Central /ID# 254325
🇵🇹Lisbon, Portugal
Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 254322
🇵🇹Porto, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 254324
🇵🇹Porto, Portugal
Dr. Samuel Sanchez PSC /ID# 253948
🇵🇷Caguas, Puerto Rico
Alma M. Cruz Santana, MD-Private practice /ID# 253951
🇵🇷Carolina, Puerto Rico
King Faisal Specialist Hospital and Research Centre /ID# 255279
🇸🇦Riyadh, Ar Riyad, Saudi Arabia
King Abdulaziz Medical City- National Guard Hospital /ID# 255280
🇸🇦Riyadh, Ar Riyad, Saudi Arabia
King Faisal Specialist Hospital /ID# 255539
🇸🇦Jeddah, Makkah, Saudi Arabia
King Saud University Med City /ID# 255282
🇸🇦Riyadh, Saudi Arabia
National Skin Centre /ID# 255242
🇸🇬Singapore, Central Singapore, Singapore
National University Hospital /ID# 254943
🇸🇬Singapore, Singapore
Univerzitná nemocnica Bratislava - Nemocnica Ružinov /ID# 254157
🇸🇰Bratislava, Bratislavsky Kraj, Slovakia
Univerzitna nemocnica L. Pasteura Kosice /ID# 254136
🇸🇰Košice, Kosicky Kraj, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 254155
🇸🇰Nove Zamky, Nitriansky Kraj, Slovakia
Univerzitna nemocnica Martin /ID# 254153
🇸🇰Martin, Zilinsky Kraj, Slovakia
Fakultna nemocnica Trnava /ID# 254137
🇸🇰Trnava, Slovakia
Hospital Universitari de Bellvitge /ID# 254982
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 253924
🇪🇸Majadahonda, Madrid, Spain
Hospital de Manises /ID# 253867
🇪🇸Manises, Valencia, Spain
Hospital Santa Creu i Sant Pau /ID# 253869
🇪🇸Barcelona, Spain
Hospital General de Granollers /ID# 253873
🇪🇸Barcelona, Spain
Hospital Universitario Virgen de las Nieves /ID# 253870
🇪🇸Granada, Spain
Hospital Universitario Ramon y Cajal /ID# 253871
🇪🇸Madrid, Spain
Hospital Universitario y Politecnico La Fe /ID# 253868
🇪🇸Valencia, Spain
Karolinska University Hospital Solna /ID# 254808
🇸🇪Solna, Stockholms Lan, Sweden
Sahlgrenska Universitetssjukhuset /ID# 254807
🇸🇪Göteborg, Vastra Gotalands Lan, Sweden
Kantonsspital St. Gallen /ID# 255243
🇨🇭St. Gallen, Sankt Gallen, Switzerland
University Hospital Zurich /ID# 254642
🇨🇭Zurich, Zuerich, Switzerland
Inselspital, Universitaetsspital Bern /ID# 254736
🇨🇭Bern, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 254031
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
National Taiwan University Hospital /ID# 254030
🇨🇳Taipei City, Taipei, Taiwan
Changhua Christian Hospital /ID# 254032
🇨🇳Changhua City, Changhua County, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 254033
🇨🇳Taoyuan City, Taiwan
Gulhane Egitim ve Arastirma Hastanesi /ID# 253919
🇹🇷Ankara, Turkey
Uludag University Medical Faculty /ID# 253806
🇹🇷Bursa, Turkey
Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 253824
🇹🇷Istanbul, Turkey
Erciyes University Medical Faculty /ID# 253804
🇹🇷Kayseri, Turkey
Ondokuz Mayis Universitesi /ID# 254034
🇹🇷Samsun, Turkey
Chelsea and Westminster Hospital /ID# 254190
🇬🇧London, Greater London, United Kingdom
University Hospital Southampton NHS Foundation Trust /ID# 254531
🇬🇧Southampton, Hampshire, United Kingdom
UH Coventry & Warwickshire /ID# 256909
🇬🇧Coventry, Warwickshire, United Kingdom
Leeds Teaching Hospitals NHS Trust /ID# 254616
🇬🇧Leeds, West Yorkshire, United Kingdom
Northern Care Alliance NHS Group /ID# 256910
🇬🇧Salford, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 256803
🇬🇧Tooting, United Kingdom
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