Effects of estradiol on cognitive function in elderly men with mild cognitive impairment

Completed

• Conditions: Mild cognitive impairment; Mental and Behavioural Disorders; Cognitive disorder

• Registration Number: ISRCTN55070842
• Lead Sponsor: Institute for the Study of Aging (USA)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-14
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

1. Male with mild cognitive impairment (Mini-Mental State Examination [MMSE] of 26 to 30)
2. Between the ages of 55 to 98
3. Hypertension was well controlled
4. Had a caregiver

Exclusion Criteria

1. Carcinoma of the prostate, hypercalcaemia, metabolic diseases, severe Chronic Obstuctive Pulmonary Disease (COPD) and renal insufficiency
2. Clotting abnormality, hyper-coagulable states, sleep apnoea
3. Patients on coumadin with Deep Vein Thrombosis (DVT) (or with a known clotting disorder) and diabetes (if uncontrolled)
4. Liver disease, unstable coronary artery disease, history of cerebrovascular accident, recent classical migraines, thrombophlebitis or thromboembolic disease
5. Must not be on any other cognitive enhancing treatment. If so, must be washed-out for 30 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Mini-Mental Status Exam (MMSE)<br>2. Alzheimer's Disease Assessment Scale (ADAS)<br>3. Neuropsychatric Inventory (NPI)<br>4. Clinicial impression based on interview (CIBIC)

Secondary Outcome Measures

Name	Time	Method
Blood test results.